{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:57:02Z","timestamp":1788209822945,"version":"build-2803163510"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Previous studies using mouse models of\n            <jats:italic>Streptococcus pyogenes<\/jats:italic>\n            necrotizing fasciitis demonstrated that clindamycin had greater efficacy than penicillin. Frequently both agents are used concurrently in the treatment of severe\n            <jats:italic>S. pyogenes<\/jats:italic>\n            infections. This study investigated interactions between penicillin and clindamycin. E-test and broth microdilution assays suggested additivity or indifference, while timed-killing assays demonstrated concentration-dependent variable effects. Timed-kill studies utilizing clinical concentrations suggest that there is no antagonism with the combination of drugs but that the combination does not have a bactericidal advantage over either penicillin or clindamycin alone.\n          <\/jats:p>","DOI":"10.1128\/aac.42.5.1266","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:31:56Z","timestamp":1539045116000},"page":"1266-1268","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["In Vitro Antimicrobial Effects of Various Combinations of Penicillin and Clindamycin against Four Strains of\n            <i>Streptococcus pyogenes<\/i>"],"prefix":"10.1128","volume":"42","author":[{"given":"Dennis L.","family":"Stevens","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Section, VA Medical Center, Boise, and Idaho State University College of Pharmacy, Pocatello, Idaho, and University of Washington School of Medicine, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Madaras-Kelly","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Section, VA Medical Center, Boise, and Idaho State University College of Pharmacy, Pocatello, Idaho, and University of Washington School of Medicine, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Richards","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Infectious Diseases Section, VA Medical Center, Boise, and Idaho State University College of Pharmacy, Pocatello, Idaho, and University of Washington School of Medicine, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1001\/archinte.1985.00360060076010","article-title":"Streptococcal myositis.","volume":"145","author":"Adams E. M.","year":"1985","unstructured":"Adams E. M. Gudmundsson S. Yocum D. E. Haselby R. C. Craig W. A. Sundstrom W. R. Streptococcal myositis. Arch. Intern. Med. 145 1985 1020 1023","journal-title":"Arch. Intern. Med."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90207-4"},{"key":"e_1_3_2_4_2","unstructured":"American Society of Health-System Pharmacists\n          AHFS drug information 97: penicillin.\n          1997\n          American Society of Health-System Pharmacists Inc.\n          Bethesda Md"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00006454-198509000-00010","article-title":"Role of beta-lactamase-producing bacteria in the failure of penicillin to eradicate group A streptococci.","volume":"4","author":"Brook I.","year":"1985","unstructured":"Brook I. Role of beta-lactamase-producing bacteria in the failure of penicillin to eradicate group A streptococci. Pediatr. Infect. Dis. 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