{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:14:29Z","timestamp":1791976469859,"version":"4.4.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activity of moxifloxacin (BAY 12-8039) against a\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            type 3 strain (MIC and minimum bactericidal concentration [MBC] of moxifloxacin, 0.06 and 0.25 \u03bcg\/ml, respectively; MIC and MBC of ceftriaxone, 0.03 and 0.06 \u03bcg\/ml, respectively) was determined in vitro and in a rabbit model of meningitis. Despite comparable bactericidal activity, 10 \u03bcg of moxifloxacin per ml released lipoteichoic and teichoic acids less rapidly than 10 \u03bcg of ceftriaxone per ml in vitro. Against experimental meningitis, 10 mg of moxifloxacin per kg of body weight per ml reduced the bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as ceftriaxone did (mean \u00b1 standard deviation, \u22120.32 \u00b1 0.14 versus \u22120.39 \u00b1 0.11 \u0394log CFU\/ml\/h). The activity of moxifloxacin could be described by a sigmoid dose-response curve with a maximum effect of \u22120.33 \u0394logCFU\/ml\/h and with a dosage of 1.4 mg\/kg\/h producing a half-maximal effect. Maximum tumor necrosis factor activity in CSF was observed later with moxifloxacin than with ceftriaxone (5 versus 2 h after the initiation of treatment). At 10 mg\/kg\/h, the concentrations of moxifloxacin in CSF were 3.8 \u00b1 1.2 \u03bcg\/ml. Adjunctive treatment with dexamethasone at 1 mg\/kg prior to the initiation of antibiotic treatment only marginally reduced the concentrations of moxifloxacin in CSF (3.3 \u00b1 0.6 \u03bcg\/ml). In conclusion, moxifloxacin may qualify for use in the treatment of\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            meningitis.\n          <\/jats:p>","DOI":"10.1128\/aac.42.6.1397","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:32:51Z","timestamp":1539045171000},"page":"1397-1401","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Moxifloxacin in the Therapy of Experimental Pneumococcal Meningitis"],"prefix":"10.1128","volume":"42","author":[{"given":"H.","family":"Schmidt","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dalhoff","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Bayer AG, Wuppertal,2 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Stuertz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Trostdorf","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Schneider","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kohlsdorfer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Bayer AG, Wuppertal,2 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Bru\u0308ck","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Neuropathology,3 University of Go\u0308ttingen, Go\u0308ttingen, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nau","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1432-1033.1992.tb17143.x","article-title":"The structure of pneumococcal lipoteichoic acid.","volume":"207","author":"Behr T.","year":"1992","unstructured":"Behr T. 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