{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:26:07Z","timestamp":1762867567258},"reference-count":22,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The comparative in vitro activity of HMR 3004 and HMR 3647, new ketolide antibiotics, was tested by a standard agar dilution technique against 221 pneumococcal strains, including isolates with intermediate levels of resistance to penicillin and erythromycin-resistant isolates. The ketolides were more active than other macrolides and showed excellent activity against erythromycin-resistant strains. All the strains were inhibited by \u22642 \u03bcg of HMR 3004\/ml or by \u22640.5 \u03bcg of HMR 3647\/ml.<\/jats:p>","DOI":"10.1128\/aac.42.6.1509","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:32:51Z","timestamp":1539045171000},"page":"1509-1511","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["In Vitro Activities of the New Ketolide Antibiotics HMR 3004 and HMR 3647 against\n            <i>Streptococcus pneumoniae<\/i>\n            in Germany"],"prefix":"10.1128","volume":"42","author":[{"given":"Ralf Rene\u0301","family":"Reinert","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital (RWTH) Aachen, Aachen, Germany1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre\u0301","family":"Bryskier","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Hoechst Marion Roussel, Romainville, France2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Lu\u0308tticken","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital (RWTH) Aachen, Aachen, Germany1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.77"},{"key":"e_1_3_2_3_2","unstructured":"Barry\n              A. L.\n              Brown\n              S. D.\n              Fuchs\n              P. C.\n          Antipneumococcal activity of a ketolide (HMR 3647) and seven related drugs in vitro abstr. F-107\n          Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1997\n          164\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/BF01709263","article-title":"In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae.","volume":"16","author":"Barry A.","year":"1997","unstructured":"Barry A. Fuchs P. Brown S. In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. Eur. J. Clin. Microbiol. Infect. Dis. 16 1997 767 769","journal-title":"Eur. J. Clin. Microbiol. 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