{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:23:21Z","timestamp":1791098601358,"version":"4.1.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The \u03b2-lactamases in 154 clinical\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            strains were studied. Susceptibilities to \u03b2-lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            strains susceptible to antimycobacterial drugs and in nine multiresistant strains. All 154\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            isolates showed a single chromosomal \u03b2-lactamase pattern (pI 4.9 and 5.1).\n            <jats:italic>M. tuberculosis<\/jats:italic>\n            \u03b2-lactamase hydrolyzes cefotaxime with a maximum rate of 22.5 \u00b1 2.19 IU\/liter (strain 1382). Neither amoxicillin, carbenicillin, cefotaxime, ceftriaxone, nor aztreonam was active alone. Except for aztreonam, \u03b2-lactam combinations with clavulanate produced better antimycobacterial activity.\n          <\/jats:p>","DOI":"10.1128\/aac.42.6.1524","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:32:51Z","timestamp":1539045171000},"page":"1524-1526","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Contribution of \u03b2-Lactamases to \u03b2-Lactam Susceptibilities of Susceptible and Multidrug-Resistant\n            <i>Mycobacterium tuberculosis<\/i>\n            Clinical Isolates"],"prefix":"10.1128","volume":"42","author":[{"given":"C.","family":"Segura","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratori de Refere\u0300ncia de Catalunya1 and"},{"name":"<!--label omitted: 2-->Departament de Gene\u0301tica y Microbiolog\u0131\u0301a,2Universitat Auto\u0300noma de Barcelona, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salvado\u0301","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratori de Refere\u0300ncia de Catalunya1 and"},{"name":"<!--label omitted: 2-->Departament de Gene\u0301tica y Microbiolog\u0131\u0301a,2Universitat Auto\u0300noma de Barcelona, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Collado","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Institut Municipal d\u2019Investigacio\u0301Me\u0300dica,3 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chaves","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Institut Municipal d\u2019Investigacio\u0301Me\u0300dica,3 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Coira","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Institut Municipal d\u2019Investigacio\u0301Me\u0300dica,3 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1042\/bj2710729","article-title":"Characterization of a betalactamase produced in Mycobacterium fortuitum D316.","volume":"271","author":"Amicosante G.","year":"1990","unstructured":"Amicosante G. Franceschini N. Segatore B. Oratore A. Characterization of a betalactamase produced in Mycobacterium fortuitum D316. Biochem. J. 271 1990 729 734","journal-title":"Biochem. J."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.257.5073.1055"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1164\/ajrccm\/144.4.745","article-title":"Resurgent tuberculosis in New York City: human immunodeficiency virus, homelessness, and the decline of tuberculosis control programs.","volume":"144","author":"Brudney K.","year":"1992","unstructured":"Brudney K. Dobkin J. Resurgent tuberculosis in New York City: human immunodeficiency virus, homelessness, and the decline of tuberculosis control programs. Am. Rev. Respir. Dis. 144 1992 745 749","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_5_2","first-page":"280","article-title":"Beta-lactamase (penicillinase, cephalosporinase)","volume":"4","author":"Bush K.","year":"1984","unstructured":"Bush K. Sykes R. B. Beta-lactamase (penicillinase, cephalosporinase) Methods of enzymatic analysis 3rd ed. Bergmeyer H. U. 4 1984 280 284 Verlag Chemie Weinheim, Germany","journal-title":"Methods of enzymatic analysis"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.1.6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02075706"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.1.132"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.12.2620"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.24.3.429"},{"key":"e_1_3_2_12_2","first-page":"1065","article-title":"Genetic relatedness among strains of Mycobacterium tuberculosis complex.","volume":"133","author":"Eisenach K. D.","year":"1986","unstructured":"Eisenach K. D. Crawford J. T. Bates J. H. Genetic relatedness among strains of Mycobacterium tuberculosis complex. Am. Rev. Respir. Dis. 133 1986 1065 1068","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1128\/jcm.26.7.1349-1352.1988","article-title":"Rapid detection and identification of pathogenic mycobacteria by combining radiometric and nucleic acid probe methods.","volume":"23","author":"Ellner P. D.","year":"1988","unstructured":"Ellner P. D. Kiehn T. E. Camarata R. Hosmer M. Rapid detection and identification of pathogenic mycobacteria by combining radiometric and nucleic acid probe methods. J. Clin. Microbiol. 23 1988 1349 1352","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.9.2427-2431.1992"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1182"},{"key":"e_1_3_2_16_2","first-page":"640","article-title":"Bacteriophage types of Mycobacterium tuberculosis in the United States.","volume":"125","author":"Jones W. D.","year":"1982","unstructured":"Jones W. D. Good R. C. Thompson N. J. Kely G. D. Bacteriophage types of Mycobacterium tuberculosis in the United States. Am. Rev. Respir. Dis. 125 1982 640 643","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0962-8479(95)90557-X","article-title":"Distribution and characterization of betalactamases of mycobacteria and related organisms.","volume":"76","author":"Kwon H. H.","year":"1995","unstructured":"Kwon H. H. Tomioka H. Saito H. Distribution and characterization of betalactamases of mycobacteria and related organisms. Tubercle Lung Dis. 76 1995 141 148","journal-title":"Tubercle Lung Dis."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-88-1-169"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1378\/chest.99.4.1025","article-title":"Amoxicillin clavulanic acid for treating drug resistant Mycobacterium tuberculosis.","volume":"99","author":"Nadler J. P.","year":"1991","unstructured":"Nadler J. P. Berger J. Nord J. A. Cofsky R. Saxena M. Amoxicillin clavulanic acid for treating drug resistant Mycobacterium tuberculosis. Chest 99 1991 1025 1026","journal-title":"Chest"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.20.5.1015-1016.1984"},{"key":"e_1_3_2_21_2","first-page":"27","article-title":"Determinaci\u00f3n orientativa del espectro de hidr\u00f3lisis de las betalactamasas de enterobacteri\u00e1ceas y de Pseudomonas aeruginosa.","volume":"33","author":"Roy C.","year":"1984","unstructured":"Roy C. Segura C. Tirado M. Reig R. Determinaci\u00f3n orientativa del espectro de hidr\u00f3lisis de las betalactamasas de enterobacteri\u00e1ceas y de Pseudomonas aeruginosa. Rev. Diagn. Biol. 33 1984 27 32","journal-title":"Rev. Diagn. Biol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/19.1.59","article-title":"Comparison of four betalactamase inhibitors in combination with ampicillin against Mycobacterium tuberculosis.","volume":"19","author":"Sorg T. B.","year":"1987","unstructured":"Sorg T. B. Cynamon M. H. Comparison of four betalactamase inhibitors in combination with ampicillin against Mycobacterium tuberculosis. J. Antimicrob. Chemother. 19 1987 59 64","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.3.393"},{"key":"e_1_3_2_24_2","first-page":"1436","article-title":"Family Mycobacteriaceae","volume":"2","author":"Wayne L. G.","year":"1986","unstructured":"Wayne L. G. Kubica G. P. Family Mycobacteriaceae Bergey\u2019s manual of systematic bacteriology Sneath P. H. A. Mair N. S. Sharpe M. E. Holt J. G. 2 1986 1436 1457 Williams and Wilkins Baltimore, Md","journal-title":"Bergey\u2019s manual of systematic bacteriology"},{"key":"e_1_3_2_25_2","unstructured":"Wong\n              C.\n              Cynamon\n              M.\n              Gavalchin\n              J.\n          Characterization of the \u03b2-lactamase of Mycobacterium tuberculosis abstr. U-85\n          Abstracts of the 89th Annual Meeting of the American Society for Microbiology 1989.\n          1989\n          169\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1164\/ajrccm\/145.3.657","article-title":"Betalactamase inhibitors and the inducibility of the betalactamase of Mycobacterium tuberculosis.","volume":"145","author":"Zhang Y.","year":"1992","unstructured":"Zhang Y. Steingrube V. Wallace R. J. Betalactamase inhibitors and the inducibility of the betalactamase of Mycobacterium tuberculosis. Am. Rev. Respir. Dis. 145 1992 657 660","journal-title":"Am. Rev. Respir. Dis."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.6.1524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.6.1524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:45:54Z","timestamp":1645458354000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.6.1524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["10.1128\/AAC.42.6.1524"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.6.1524","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6]]},"assertion":[{"value":"1997-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}