{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:56:14Z","timestamp":1775246174169,"version":"3.50.1"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Moxifloxacin is a new 8-methoxyquinolone with high activity against gram-positive bacteria, including penicillin-resistant pneumococci. In an experimental meningitis model, we studied the pharmacokinetics of moxifloxacin in infected and uninfected rabbits and evaluated the antibiotic efficacies of moxifloxacin, ceftriaxone, and vancomycin against a penicillin-resistant\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    strain (penicillin, ceftriaxone, vancomycin, and moxifloxacin MICs were 1, 0.5, 0.5, and 0.125 \u03bcg\/ml, respectively). Moxifloxacin entered cerebrospinal fluid (CSF) readily, with peak values within 15 to 30 min after bolus intravenous infusion and with a mean percent penetration into normal and purulent CSF of approximately 50 and 80%, respectively. The bactericidal effect of moxifloxacin was concentration dependent, and regrowth was seen only when the concentration of moxifloxacin in CSF was below the minimal bactericidal concentration. All antibiotic-treated groups (moxifloxacin given in two doses of 40 mg\/kg of body weight, moxifloxacin in two 20-mg\/kg doses, ceftriaxone in one 125-mg\/kg dose, and vancomycin in two 20-mg\/kg doses) had significantly higher reductions in CSF bacterial concentration than the untreated group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Moxifloxacin was as effective as vancomycin and ceftriaxone in reducing bacterial counts at all time points tested (3, 5, 10, and 24 h). Moreover, moxifloxacin given in two 40-mg\/kg doses resulted in a significantly higher reduction in CSF bacterial concentration (in log\n                    <jats:sub>10<\/jats:sub>\n                    CFU per milliliter) than vancomycin within 3 h after the start of antibiotic treatment (3.49 [2.94 to 4.78] versus 2.50 [0.30 to 3.05];\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). These results indicate that moxifloxacin could be useful in the treatment of meningitis, including penicillin-resistant pneumococcal meningitis.\n                  <\/jats:p>","DOI":"10.1128\/aac.42.7.1706","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:33:03Z","timestamp":1539030783000},"page":"1706-1712","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["Evaluation of Moxifloxacin, a New 8-Methoxyquinolone, for Treatment of Meningitis Caused by a PenicillinResistant Pneumococcus in Rabbits"],"prefix":"10.1128","volume":"42","author":[{"given":"Christian","family":"\u00d8stergaard","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Microbiology, Department of Clinical Microbiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Klitm\u00f8ller S\u00f8rensen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Microbiology, Department of Clinical Microbiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Dahl Knudsen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Microbiology, Department of Clinical Microbiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Frimodt-M\u00f8ller","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Microbiology, Department of Clinical Microbiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1093\/clinids\/24.Supplement_2.S213","article-title":"The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: current antibiotic therapy in the 1990s.","volume":"24","author":"Bradley J. 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