{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:54:43Z","timestamp":1764402883561},"reference-count":19,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In vitro and in vivo efficacies of NS-718, a lipid nanosphere-encapsulated amphotericin B (AMPH-B), have been studied. Of the tested AMPH-B formulations, NS-718 had the lowest MIC for\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            . In a murine model, low-dose therapy (0.8 mg\/kg of body weight) with NS-718 showed higher efficacy than that with AmBisome. High-dose therapy (2.0 mg\/kg) with NS-718 was much more effective than those with Fungizone and AmBisome. In mice treated with a high dose of NS-718, only a few yeast cells had grown in lung by 7 days after inoculation. A pharmacokinetic study showed higher concentrations of AMPH-B in lung following administration of NS-718 than after administration of AmBisome. Our results indicated that NS-718, a new AMPH-B formulation, is a promising antifungal agent for treatment of pulmonary cryptococcosis and could be the most effective antifungal agent against\n            <jats:italic>C. neoformans<\/jats:italic>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/aac.42.7.1722","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:03Z","timestamp":1539045183000},"page":"1722-1725","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of NS-718, a Novel Lipid Nanosphere-Encapsulated Amphotericin B, against\n            <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1128","volume":"42","author":[{"given":"Mohammad Ashraf","family":"Hossain","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigefumi","family":"Maesaki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kakeya","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiro","family":"Noda","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Yanagihara","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Sasaki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Hirakata","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Tomono","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Tashiro","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.4.512"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.2.294"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.2.414"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-5173(97)00194-4","article-title":"Poly(\u025b-caprolacton) nanoparticles as an alternative way to reduce amphotericin B toxicity.","volume":"158","author":"Espuelas M. 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