{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:31:10Z","timestamp":1761060670024},"reference-count":28,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Y-688 is a new fluoroquinolone with increased activity against ciprofloxacin-resistant staphylococci. The MICs of Y-688 and other quinolones were determined for 58 isolates of ciprofloxacin-resistant and methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (MRSA). The MICs at which 50% and 90% of bacteria were inhibited were \u2265128 and \u2265128 mg\/liter, respectively, for ciprofloxacin, 16 and 32 mg\/liter, respectively, for sparfloxacin, and 0.25 and 1 mg\/liter, respectively, for Y-688. This new quinolone was further tested in rats with experimental endocarditis due to either of two isolates of ciprofloxacin-resistant MRSA (namely, P8\/128 and CR1). Infected animals were treated for 3 days with ciprofloxacin, vancomycin, or Y-688. Antibiotics were administered through a computerized pump to simulate human-like pharmacokinetics in the serum of rats. The anticipated peak and trough levels of Y-688 were 4 and 1 mg\/liter at 0.5 and 12 h, respectively. Treatment with ciprofloxacin was ineffective. Vancomycin significantly decreased vegetation bacterial counts for both organisms (\n            <jats:italic>P<\/jats:italic>\n            \u2272 0.05). In contrast, Y-688 only marginally decreased vegetation bacterial counts (\n            <jats:italic>P<\/jats:italic>\n            \u2273 0.05). Moreover, several vegetation that failed Y-688 treatment grew staphylococci for which the MICs of the test antibiotic were increased two to eight times. Y-688 also selected for resistance in vitro, and isolates for which the MICs were increased eight times emerged at a frequency of ca. 10\n            <jats:sup>\u22128<\/jats:sup>\n            . Thus, in spite of its low MIC for ciprofloxacin-resistant MRSA, Y-688 failed in vivo and its use carried the risk of resistance selection. The fact that ciprofloxacin-resistant staphylococci became rapidly resistant to this potent new drug suggests that the treatment of ciprofloxacin-resistant MRSA with new quinolones might be more problematic than expected.\n          <\/jats:p>","DOI":"10.1128\/aac.42.8.1889","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:13Z","timestamp":1539045193000},"page":"1889-1894","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Y-688, a New Quinolone Active against Quinolone-Resistant\n            <i>Staphylococcus aureus<\/i>\n            : Lack of In Vivo Efficacy in Experimental Endocarditis"],"prefix":"10.1128","volume":"42","author":[{"given":"J. M.","family":"Entenza","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Marchetti","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Glauser","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Moreillon","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.4.575"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013983"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.25.3.319"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.5.938"},{"key":"e_1_3_2_6_2","unstructured":"Cr\u00e9mieux\n              A. C.\n              Saleh-Mghir\n              A.\n              Vallois\n              J. M.\n              Ottaviani\n              M.\n              Pocidalo\n              J. J.\n              Carbon\n              C.\n          Pattern and diffusion of three quinolones throughout infected cardiac vegetations studied by autoradiography abstr. 357\n          Program and abstracts of the 31st Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1991\n          158\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_7_2","unstructured":"Entenza\n              J. M.\n              Blatter\n              M.\n              Francioli\n              P.\n              Glauser\n              M. P.\n              Moreillon\n              P.\n          Sparfloxacin treatment of experimental endocarditis due to ciprofloxacin-susceptible or laboratory-selected resistant methicillin-resistant Staphylococcus aureus abstr. B-9\n          Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1996\n          23\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.12.2683"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.1.70"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/infdis\/170.1.100","article-title":"Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis.","volume":"170","author":"Entenza J. M.","year":"1994","unstructured":"Entenza J. M. Fluckiger U. Glauser M. P. Moreillon P. Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis. J. Infect. Dis. 170 1994 100 109","journal-title":"J. Infect. 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A.","year":"1994","unstructured":"Garcia-Rodriguez J. A. Garcia J. E. Garcia Garcia M. I. Fresnadillo M. J. Trujillano I. Garcia Sanchez E. In vitro activity of four new fluoroquinolones. J. Antimicrob. Chemother. 34 1994 53 64","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.5.1166"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1128\/AAC.35.9.1911","article-title":"Emergence of quinolone resistance among clinical isolates of methicillin-resistant Staphylococcus aureus in Ontario.","volume":"3","author":"Harnett N.","year":"1991","unstructured":"Harnett N. Brown S. Krishnan C. Emergence of quinolone resistance among clinical isolates of methicillin-resistant Staphylococcus aureus in Ontario. Antimicrob. Agents Chemother. 3 1991 1911 1913","journal-title":"Antimicrob. 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F-190\n          Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1996\n          146\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.5.993"},{"key":"e_1_3_2_21_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A3.\n          1993\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.2.163"},{"key":"e_1_3_2_23_2","unstructured":"Sanders C. C. W. E. Sanders Jr. and K. S. Thomson. 1995. Fluoroquinolone resistance in staphylococci: new challenges. Eur. J. Clin. Microbiol. Infect. Dis. 14 (Suppl. 1) : 6\u201311."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.4.593"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-42-3-214"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.1.124"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.2.4.378"},{"key":"e_1_3_2_28_2","unstructured":"Yokoyama\n              Y.\n              Morimoto\n              M.\n              Iwao\n              E.\n              Yamamoto\n              K.\n              Honjo\n              K.\n              Hyrayama\n              F.\n              Ikeda\n              Y.\n          Y-688 a new fluoroquinolone with high activity against quinolone-resistant gram-positive bacteria abstr. F-191\n          Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1995\n          146\n          American Society for Microbiology\n          Washington DC"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.12.6942-6949.1990"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.8.1889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.8.1889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:49:09Z","timestamp":1645458549000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.8.1889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["10.1128\/AAC.42.8.1889"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.8.1889","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]},"assertion":[{"value":"1998-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}