{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:50:11Z","timestamp":1781344211061,"version":"3.54.1"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            is a major etiological agent in gastroduodenal disorders. The adhesion of\n            <jats:italic>H. pylori<\/jats:italic>\n            to human gastric epithelial cells is the initial step of\n            <jats:italic>H. pylori<\/jats:italic>\n            infection. Inhibition of\n            <jats:italic>H. pylori<\/jats:italic>\n            adhesion is thus a therapeutic target in the prevention of\n            <jats:italic>H. pylori<\/jats:italic>\n            infection. Experiments were performed to evaluate the effect of rebamipide, a novel antiulcer agent, on\n            <jats:italic>H. pylori<\/jats:italic>\n            adhesion to gastric epithelial cells. MKN-28 and MKN-45 cells, derived from human gastric carcinomas, were used as target cells. Ten\n            <jats:italic>H. pylori<\/jats:italic>\n            strains isolated from patients with chronic gastritis and gastric ulcer were used in the study. We evaluated the effect of rebamipide on\n            <jats:italic>H. pylori<\/jats:italic>\n            adhesion to MKN-28 and MKN-45 cells quantitatively using our previously established enzyme-linked immunosorbent assay. The adhesion of\n            <jats:italic>H. pylori<\/jats:italic>\n            to MKN-28 and MKN-45 cells was significantly inhibited by pretreatment of these cells with 100 \u03bcg of rebamipide per ml. However, the adhesion was not affected by the pretreatment of\n            <jats:italic>H. pylori<\/jats:italic>\n            with rebamipide. On the other hand, the viabilities of\n            <jats:italic>H. pylori<\/jats:italic>\n            , MKN-28 cells, and MKN-45 cells were not affected by rebamipide. Our studies suggest that rebamipide inhibits the adhesion of\n            <jats:italic>H. pylori<\/jats:italic>\n            to gastric epithelial cells.\n          <\/jats:p>","DOI":"10.1128\/aac.42.8.1895","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:13Z","timestamp":1539045193000},"page":"1895-1899","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Effect of Rebamipide, a Novel Antiulcer Agent, on\n            <i>Helicobacter pylori<\/i>\n            Adhesion to Gastric Epithelial Cells"],"prefix":"10.1128","volume":"42","author":[{"given":"Shunji","family":"Hayashi","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, Jichi Medical School, Tochigi-ken 329-0498,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo 060-8638,2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichi","family":"Amano","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Central Research Laboratory, Akita University School of Medicine, Akita 010-8543,3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Isogai","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Animal Experimentation Center4 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Isogai","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Department of Hygiene, Health Sciences University of Hokkaido, Hokkaido 061-0293,5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Aihara","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Otsuka Pharmaceutical Co., Ltd., Tokushima 771-0192,6 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Otsuka Pharmaceutical Co., Ltd., Tokushima 771-0192,6 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Asaka","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo 060-8638,2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yokota","sequence":"additional","affiliation":[{"name":"<!--label omitted: 7-->Department of Bacteriology, Okayama University Medical School, Okayama 700-8558,7 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Oguma","sequence":"additional","affiliation":[{"name":"<!--label omitted: 7-->Department of Bacteriology, Okayama University Medical School, Okayama 700-8558,7 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"<!--label omitted: 8-->Department of Microbiology,8 Sapporo Medical University School of Medicine, Sapporo 060-8556,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Hirai","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, Jichi Medical School, Tochigi-ken 329-0498,1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.11.2896-2906.1988"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.3.674-683.1993"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90938-D"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb01448.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1043-6618(05)80023-4","article-title":"Effects of rebamipide on gastric cell damage by Helicobacter pylori-stimulated human neutrophils.","volume":"32","author":"Han B. 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