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By the completion of both 12 and 24 weeks of therapy, molecular hybridization studies of the liver tissue revealed that the viral DNA, RNA, and protein levels were significantly reduced compared to those in the placebo-treated controls. Penciclovir treatment for 12 or 24 weeks was not associated with any toxicity, establishing the efficacy and safety of long-term penciclovir therapy in chronic DHBV infection.<\/jats:p>","DOI":"10.1128\/aac.42.8.2132","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:13Z","timestamp":1539045193000},"page":"2132-2137","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Long-Term Therapy with the Guanine Nucleoside Analog Penciclovir Controls Chronic Duck Hepatitis B Virus Infection In Vivo"],"prefix":"10.1128","volume":"42","author":[{"given":"Enjarn","family":"Lin","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Fairfield, Victoria 3078, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Luscombe","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Fairfield, Victoria 3078, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danni","family":"Colledge","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Fairfield, Victoria 3078, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Fairfield, Victoria 3078, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Locarnini","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Fairfield, Victoria 3078, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890310204"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1097\/00007890-199457120-00003","article-title":"Prostaglandin E plus famciclovir: a new concept for the treatment of severe hepatitis B after liver transplantation.","volume":"57","author":"Boker K. 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