{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:13:00Z","timestamp":1791162780077,"version":"4.1.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Amphotericin B (AmB) has been used as a second-line treatment of visceral leishmaniasis, particularly in human immunodeficiency virus-positive patients. AmB median effective doses (ED\n            <jats:sub>50<\/jats:sub>\n            s) were determined on an isolate obtained before any treatment and on a second isolate obtained 4 years later from the same AmB-treated patient. ED\n            <jats:sub>50<\/jats:sub>\n            s were similar (0.059 and 0.067 mg\/kg of body weight, respectively), demonstrating the first evidence of AmB ED\n            <jats:sub>50<\/jats:sub>\n            stability of\n            <jats:italic>Leishmania infantum<\/jats:italic>\n            after a long-term drug exposure. An isoenzymatic study was performed in order to verify that the second isolate originated from the same parasite as the first isolate. The present case report showed that treatment failure was not due to parasite resistance in spite of a prolonged exposure to the drug.\n          <\/jats:p>","DOI":"10.1128\/aac.42.8.2141","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:13Z","timestamp":1539045193000},"page":"2141-2143","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["<i>Leishmania infantum<\/i>\n            : Lack of Parasite Resistance to Amphotericin B in a Clinically Resistant Visceral Leishmaniasis"],"prefix":"10.1128","volume":"42","author":[{"given":"Remy","family":"Durand","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Parasitologie1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Paul","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Pharmacotechnie, Service de Pharmacie,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Pratlong","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Laboratoire d\u2019Ecologie Me\u0301dicale et Pathologie Parasitaire, 34090 Montpellier,3 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Rivollet","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Parasitologie1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Dubreuil-Lemaire","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Service d\u2019Immunologie Clinique,4 CHU Henri Mondor, 94010 Cre\u0301teil, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Houin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Parasitologie1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Astier","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Pharmacotechnie, Service de Pharmacie,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Deniau","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Parasitologie1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.2.298"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0035-9203(85)90197-X","article-title":"Visceral leishmaniasis unresponsive to antimonial drugs. 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