{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:25:26Z","timestamp":1785403526473,"version":"3.56.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Immune-competent ICR and BALB\/c athymic (nude) mice were infected intravenously with\n            <jats:italic>Histoplasma capsulatum<\/jats:italic>\n            and treated with either fluconazole or nikkomycin Z or 5% dextrose (controls). In immune-competent ICR mice, fluconazole and nikkomycin Z both prolonged survival when given at 5 mg\/kg of body weight twice daily. When administered in doses as low as 2.5 mg\/kg twice daily, nikkomycin Z reduced fungal counts in both the spleen and liver. When both drugs were combined, there was no antagonism, and in combined therapy spleen and liver counts were reduced more than for either drug alone. However, nikkomycin Z had no effect on brain fungal burden. In nude mice fluconazole and nikkomycin Z had an additive effect in prolongation of survival and reduction of liver and spleen burden. Nikkomycin Z is well tolerated, is at least as effective as fluconazole, and may interact beneficially with fluconazole for treatment of murine histoplasmosis.\n          <\/jats:p>","DOI":"10.1128\/aac.42.9.2371","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:24Z","timestamp":1539045204000},"page":"2371-2374","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Efficacy of Nikkomycin Z in the Treatment of Murine Histoplasmosis"],"prefix":"10.1128","volume":"42","author":[{"given":"John R.","family":"Graybill","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Audie Murphy Memorial Veterans Hospital,1"},{"name":"<!--label omitted: 2-->University of Texas Health Science Center,2 San Antonio, Texas 78284, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->University of Texas Health Science Center,2 San Antonio, Texas 78284, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->University of Texas Health Science Center,2 San Antonio, Texas 78284, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Hector","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Shaman Pharmaceuticals, South San Francisco, California 940803"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Luther","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Audie Murphy Memorial Veterans Hospital,1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.47.100193.002445"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.48.100194.002351"},{"key":"e_1_3_2_4_2","first-page":"201","article-title":"The immune response to Histoplasma capsulatum: unearthing its secrets.","volume":"123","author":"Deepe G. S.","year":"1994","unstructured":"Deepe G. S. Jr. The immune response to Histoplasma capsulatum: unearthing its secrets. J. Lab. Clin. Med. 123 1994 201 205","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_3_2_5_2","unstructured":"Flores\n              M. E.\n              Hector\n              R. F. In vitro activity of the antifungal nikkomycin Z (SP-920704) in combination with fluconazole or itraconazole vs. yeasts abstr. F190\n          Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1996\n          133\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.18.5857-5860.1994"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.7.1685-1691.1988"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.6.1.1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.6.1284"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.4.587"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.8.2416-2419.1996"},{"key":"e_1_3_2_12_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Reference method for broth dilution antifungal susceptibility testing for yeasts: proposed standard M27-P.\n          1992\n          National Committee for Clinical Laboratory Standards\n          Villanova Pa"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1093\/infdis\/162.6.1349","article-title":"Tumor necrosis factor-\u03b1 plays a role in host defense against Histoplasma capsulatum.","volume":"162","author":"Smith J. G.","year":"1990","unstructured":"Smith J. G. Magee D. M. Williams D. W. Graybill J. R. Tumor necrosis factor-\u03b1 plays a role in host defense against Histoplasma capsulatum. J. Infect. Dis. 162 1990 1349 1353","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00005792-199011000-00004","article-title":"Disseminated histoplasmosis in the acquired immunodeficiency syndrome: clinical findings, diagnosis and treatment and review of the literature.","volume":"69","author":"Wheat L. J.","year":"1990","unstructured":"Wheat L. J. Connolly-Springfield P. A. Backer R. L. Curfman M. F. Eads M. E. Israel K. Norris S. A. Webb D. Zeckel M. L. Disseminated histoplasmosis in the acquired immunodeficiency syndrome: clinical findings, diagnosis and treatment and review of the literature. Medicine 69 1990 361 374","journal-title":"Medicine"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0002-9343(85)90427-9","article-title":"Histoplasmosis in the acquired immune deficiency syndrome.","volume":"78","author":"Wheat L. J.","year":"1985","unstructured":"Wheat L. J. Slama T. G. Zeckel M. L. Histoplasmosis in the acquired immune deficiency syndrome. Am. J. Med. 78 1985 203 210","journal-title":"Am. J. Med."},{"key":"e_1_3_2_16_2","first-page":"837","article-title":"Experimental chemotherapy of histoplasmosis in nude mice.","volume":"120","author":"Williams D. M.","year":"1979","unstructured":"Williams D. M. Graybill J. R. Drutz D. J. Experimental chemotherapy of histoplasmosis in nude mice. Am. Rev. Respir. Dis. 120 1979 837 842","journal-title":"Am. Rev. Respir. Dis."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.9.2371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.9.2371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:05:41Z","timestamp":1645459541000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.9.2371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["10.1128\/AAC.42.9.2371"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.9.2371","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]},"assertion":[{"value":"1997-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}