{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:49:09Z","timestamp":1766087349373},"reference-count":7,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]\/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable\n            <jats:italic>Candida albicans<\/jats:italic>\n            in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB\/kg \u00b7 day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB\/kg), the efficacy was equal to that of PEG-AMB-LIP.\n          <\/jats:p>","DOI":"10.1128\/aac.42.9.2431","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:24Z","timestamp":1539045204000},"page":"2431-2433","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Superior Efficacy of Liposomal Amphotericin B with Prolonged Circulation in Blood in the Treatment of Severe Candidiasis in Leukopenic Mice"],"prefix":"10.1128","volume":"42","author":[{"given":"Els W. M.","family":"van Etten","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan V.","family":"Snijders","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"van Vianen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma A. J. 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