{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:40:58Z","timestamp":1782787258549,"version":"3.54.5"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We have tested the in vitro activities of eight fluoroquinolones against 160\n            <jats:italic>Brucella melitensis<\/jats:italic>\n            strains. The most active was sitafloxacin (MIC at which 90% of the isolates are inhibited [MIC\n            <jats:sub>90<\/jats:sub>\n            ], 0.12 \u03bcg\/ml). In decreasing order, the activities (MIC\n            <jats:sub>90<\/jats:sub>\n            s) of the rest of the tested fluoroquinolones were as follows: levofloxacin, 0.5 \u03bcg\/ml; ciprofloxacin, trovafloxacin, and moxifloxacin, 1 \u03bcg\/ml; and ofloxacin, grepafloxacin, and gatifloxacin, 2 \u03bcg\/ml.\n          <\/jats:p>","DOI":"10.1128\/aac.43.1.194","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:08Z","timestamp":1539045248000},"page":"194-195","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["In Vitro Activities of Six New Fluoroquinolones against\n            <i>Brucella melitensis<\/i>"],"prefix":"10.1128","volume":"43","author":[{"given":"Ignacio","family":"Trujillano-Marti\u0301n","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Departamento de Microbiolog\u0131\u0301a y Parasitolog\u0131\u0301a, Hospital Universitario, Salamanca,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Garci\u0301a-Sa\u0301nchez","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departamento de Microbiolog\u0131\u0301a y Parasitolog\u0131\u0301a, Hospital Universitario, Salamanca,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isai\u0301as Montes","family":"Marti\u0301nez","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Unidad de Microbiolog\u0131\u0301a, Hospital Virgen del Puerto, Plasencia, Ca\u0301ceres,2 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u0301a Jose\u0301","family":"Fresnadillo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departamento de Microbiolog\u0131\u0301a y Parasitolog\u0131\u0301a, Hospital Universitario, Salamanca,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 Eli\u0301as","family":"Garci\u0301a-Sa\u0301nchez","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departamento de Microbiolog\u0131\u0301a y Parasitolog\u0131\u0301a, Hospital Universitario, Salamanca,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 A\u0301ngel","family":"Garci\u0301a-Rodri\u0301guez","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departamento de Microbiolog\u0131\u0301a y Parasitolog\u0131\u0301a, Hospital Universitario, Salamanca,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/jac\/23.3.433","article-title":"Comparison of three different regimens in the treatment of acute brucellosis: a multicenter multinational study.","volume":"23","author":"Acocella G.","year":"1990","unstructured":"Acocella G. Bertrand A. Beytout J. Durrande J. B. Garc\u0131\u0301a-Rodr\u0131\u0301guez J. A. Kosmidis J. Micoud M. Rey M. Rodr\u0131\u0301guez Zapata M. Roux J. Stahl J. P. Comparison of three different regimens in the treatment of acute brucellosis: a multicenter multinational study. J. Antimicrob. Chemother. 23 1990 433 439","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/jac\/25.2.302","article-title":"Development of ciprofloxacin resistance in Brucella melitensis.","volume":"25","author":"Al-Sibai M. B.","year":"1990","unstructured":"Al-Sibai M. B. Qadri S. M. H. Development of ciprofloxacin resistance in Brucella melitensis. J. Antimicrob. Chemother. 25 1990 302 303","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.1.150"},{"key":"e_1_3_1_5_2","unstructured":"Bergan\n              T.\n          Pharmacokinetics of the fluoroquinolones\n          The quinolones\n          2nd ed.\n              Andriole\n              V. T.\n          1998\n          143\n          182\n          Academic Press\n          San Diego Calif"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/516284"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","unstructured":"Easmon C. S. F. J. P. Crane and A. Blowers. 1986. Effect of ciprofloxacin on intracellular organisms. In-vitro and in-vivo studies. J. Antimicrob. Chemother. 18 (Suppl. D):43\u201348.","DOI":"10.1093\/jac\/18.Supplement_D.43"},{"key":"e_1_3_1_8_2","first-page":"61","article-title":"Kinetics of antimicrobial activity of ciprofloxacin against Brucella melitensis.","volume":"2","author":"Garc\u0131\u0301a-Rodr\u0131\u0301guez J. A.","year":"1989","unstructured":"Garc\u0131\u0301a-Rodr\u0131\u0301guez J. A. Garc\u0131\u0301a-S\u00e1nchez J. E. Mu\u00f1oz Bellido J. L. Garc\u0131\u0301a-S\u00e1nchez E. Trujillano I. Kinetics of antimicrobial activity of ciprofloxacin against Brucella melitensis. Rev. Esp. Quimioter. 2 1989 61 63","journal-title":"Rev. Esp. Quimioter."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.4.756"},{"key":"e_1_3_1_10_2","unstructured":"Garc\u0131\u0301a-Rodr\u0131\u0301guez J. A. J. E. Garc\u0131\u0301a-S\u00e1nchez I. Trujillano and J. L. Mu\u00f1oz Bellido. 1989. In-vitro activity of new quinolones against Brucella melitensis . Rev. Infect. Dis. 11 (Suppl. 5):S992\u2013S993."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1194"},{"key":"e_1_3_1_12_2","first-page":"189","article-title":"In-vitro activity of BAY y 3118, a novel 4-quinolone, against Brucella melitensis.","volume":"7","author":"Garc\u0131\u0301a-Rodr\u0131\u0301guez J. A.","year":"1995","unstructured":"Garc\u0131\u0301a-Rodr\u0131\u0301guez J. A. Garc\u0131\u0301a-S\u00e1nchez J. E. Trujillano-Mart\u0131\u0301n I. Garc\u0131\u0301a-S\u00e1nchez E. Garc\u0131\u0301a-Garc\u0131\u0301a M. I. Fresnadillo-Mar\u0131\u0301nez M. J. In-vitro activity of BAY y 3118, a novel 4-quinolone, against Brucella melitensis. J. Chemother. 7 1995 189 196","journal-title":"J. Chemother."},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF01977500","article-title":"In-vitro activity of ciprofloxacin against Brucella melitensis.","volume":"3","author":"Gobernado M.","year":"1984","unstructured":"Gobernado M. Cant\u00f3n E. Santos M. In-vitro activity of ciprofloxacin against Brucella melitensis. Eur. J. Clin. Microbiol. 3 1984 371","journal-title":"Eur. J. Clin. Microbiol."},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0399-077X(96)80077-1","article-title":"Ciprofloxacin plus doxycycline versus rifampicin plus doxycycline in the treatment of acute brucellosis.","volume":"26","author":"Kalo T.","year":"1996","unstructured":"Kalo T. Novi S. Nushi A. Dedja S. Ciprofloxacin plus doxycycline versus rifampicin plus doxycycline in the treatment of acute brucellosis. M\u00e9d. Maladies Infect. 26 1996 587 589","journal-title":"M\u00e9d. Maladies Infect."},{"key":"e_1_3_1_15_2","unstructured":"Kosmidis J. A. Karagounis J. Tslentis and G. K. Daikos. 1982. The combination rifampin-doxycycline in brucellosis is better than the WHO regimen. Chemioterapia 1 (Suppl. 4):107."},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0924-8579(95)00003-Q"},{"key":"e_1_3_1_17_2","unstructured":"Moyer\n              N. P.\n              Holcomb\n              L. A.\n          Brucella\n          Manual of clinical microbiology\n          6th ed.\n              Murray\n              P. R.\n              Baron\n              E. J.\n              Pfaller\n              M. A.\n              Tenover\n              F. C.\n              Yolken\n              R. H.\n          1995\n          549\n          555\n          ASM Press\n          Washington D.C"},{"key":"e_1_3_1_18_2","first-page":"483","article-title":"Susceptibility of Brucella melitensis to fluoroquinolones.","volume":"15","author":"Qadri S. M.","year":"1989","unstructured":"Qadri S. M. Akhtar M. Ueno Y. Al-Sibai M. B. Susceptibility of Brucella melitensis to fluoroquinolones. Drugs Exp. Clin. Res. 15 1989 483 485","journal-title":"Drugs Exp. Clin. Res."},{"key":"e_1_3_1_19_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0732-8893(90)90074-6","article-title":"Antibacterial activity of lomefloxacin against Brucella melitensis.","volume":"13","author":"Qadri S. M.","year":"1990","unstructured":"Qadri S. M. Al-Sedairy S. Ueno Y. Antibacterial activity of lomefloxacin against Brucella melitensis. Diagn. Microbiol. Infect. Dis. 13 1990 277 279","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_1_20_2","first-page":"128","article-title":"Susceptibility of Brucella melitensis to new fluoroquinolone PD 131628: comparison with other drugs.","volume":"39","author":"Qadri S. M.","year":"1993","unstructured":"Qadri S. M. Ueno Y. Susceptibility of Brucella melitensis to new fluoroquinolone PD 131628: comparison with other drugs. Microbiology 39 1993 128 131","journal-title":"Microbiology"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.1.194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.1.194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:11:52Z","timestamp":1645459912000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.1.194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1128\/AAC.43.1.194"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.1.194","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]},"assertion":[{"value":"1998-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}