{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:20:33Z","timestamp":1789993233101,"version":"4.0.1"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Rickettsiae are gram-negative, obligately intracellular bacteria responsible for arthropod-borne spotted fevers and typhus. Experimental studies have delineated a cluster of naturally rifampin-resistant spotted fever group species. We sequenced the 4,122- to 4,125-bp RNA polymerase \u03b2-subunit-encoding gene (\n            <jats:italic>rpoB<\/jats:italic>\n            ) from typhus and spotted fever group representatives and obtained partial sequences for all naturally rifampin-resistant species. A single point mutation resulting in a phenylalanine-to-leucine change at position 973 of the\n            <jats:italic>Rickettsia conorii rpoB<\/jats:italic>\n            sequence and present in all the rifampin-resistant species was absent in all the rifampin-susceptible species.\n            <jats:italic>rpoB<\/jats:italic>\n            -based phylogenetic relationships among these rickettsial species yielded topologies which were in accordance with previously published phylogenies.\n          <\/jats:p>","DOI":"10.1128\/aac.43.10.2400","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:30Z","timestamp":1539045210000},"page":"2400-2403","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Characterization of Mutations in the\n            <i>rpoB<\/i>\n            Gene in Naturally Rifampin-Resistant\n            <i>Rickettsia<\/i>\n            Species"],"prefix":"10.1128","volume":"43","author":[{"given":"Michel","family":"Drancourt","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 des Rickettsies CNRS UPRES-A 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Unite\u0301 des Rickettsies CNRS UPRES-A 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2590"},{"key":"e_1_3_2_3_2","unstructured":"Balayeva\n              N. M.\n              Frovola\n              O. M.\n              Genig\n              V. A.\n              Nikolskaya\n              V. N.\n          Some biological properties of antibiotic resistant mutants of Rickettsia prowazekii strain E induced by nitroso-guanidine\n          Rickettsiae and rickettsial diseases.\n              Kaz\u00e0r\n              J.\n          1985\n          85\n          91\n          Publishing House of the Slovak Academy of Sciences\n          Bratislava Slovakia"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/infdis\/164.2.433","article-title":"Randomized trial of 5-day rifampin versus 1-day doxycycline therapy for MSF.","volume":"164","author":"Bella F.","year":"1991","unstructured":"Bella F. Espero E. Uriz S. Serrano J. A. Allegre M. A. Tort J. Randomized trial of 5-day rifampin versus 1-day doxycycline therapy for MSF. J. Infect. Dis. 164 1991 433 434","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1256"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0923-2508(96)80203-8","article-title":"Rifamycin resistance in mycobacteria.","volume":"147","author":"Cole S. T.","year":"1996","unstructured":"Cole S. T. Rifamycin resistance in mycobacteria. Res. Microbiol. 147 1996 48 52","journal-title":"Res. Microbiol."},{"key":"e_1_3_2_7_2","unstructured":"Felsenstein\n              J.\n          PHYLIP: Phylogeny Inference Package version 3.5c.\n          1993\n          University of Washington\n          Seattle"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1099\/00207713-48-3-839","article-title":"Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA.","volume":"48","author":"Fournier P.-E.","year":"1998","unstructured":"Fournier P.-E. Roux V. Raoult D. Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA. Int. J. Syst. Bacteriol. 48 1998 839 849","journal-title":"Int. J. Syst. Bacteriol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(88)90330-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.3.414"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(88)90517-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-3211-9.50009-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01731581"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1432-1033.1981.tb05381.x","article-title":"The primary structure of Escherichia coli RNA polymerase. Nucleotide sequence of the rpoB gene and amino-acid sequence of the \u03b2-subunit.","volume":"116","author":"Ovchinnikov Y. A.","year":"1981","unstructured":"Ovchinnikov Y. A. Monastyrskaya G. S. Gubanov V. V. Gurey S. O. Chertov O. Y. Modyanov T. V. Grinkervich U. A. Makarova I. A. Marchenko T. V. Polovnikova I. N. Lipkin V. M. Sverdlov E. D. The primary structure of Escherichia coli RNA polymerase. Nucleotide sequence of the rpoB gene and amino-acid sequence of the \u03b2-subunit. Eur. J. Biochem. 116 1981 621 629","journal-title":"Eur. J. Biochem."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.8.2118-2124.1998"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.694"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1537"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(96)80284-1"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-2-252"},{"key":"e_1_3_2_20_2","unstructured":"Sambrook\n              J.\n              Fritsch\n              E. F.\n              Maniatis\n              T.\n          Molecular cloning: a laboratory manual\n          2nd ed.\n          1989\n          Cold Spring Harbor Laboratory Press\n          Cold Spring Harbor N.Y"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82407-3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmbi.1993.1251","article-title":"Genetic evidence for the interaction between cluster I and cluster III rifampicin resistant mutations.","volume":"231","author":"Singer M.","year":"1993","unstructured":"Singer M. Jin D. J. Walter W. A. Gross C. A. Genetic evidence for the interaction between cluster I and cluster III rifampicin resistant mutations. J. Mol. Biol. 231 1993 1 5","journal-title":"J. Mol. 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