{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:31:45Z","timestamp":1775093505294,"version":"3.50.1"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Azithromycin was given to mice and humans infected with strains of\n            <jats:italic>Orientia tsutsugamushi<\/jats:italic>\n            from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively;\n            <jats:italic>P<\/jats:italic>\n            &gt; 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.\n          <\/jats:p>","DOI":"10.1128\/aac.43.11.2817","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:33:39Z","timestamp":1539045219000},"page":"2817-2818","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Azithromycin Activities against\n            <i>Orientia tsutsugamushi<\/i>\n            Strains Isolated in Cases of Scrub Typhus in Northern Thailand"],"prefix":"10.1128","volume":"43","author":[{"given":"George","family":"Watt","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Retrovirology, U.S. Army Component,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pacharee","family":"Kantipong","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Analytical Division, Royal Thai Army Component,2 AFRIMS, Bangkok, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisada","family":"Jongsakul","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Retrovirology, U.S. Army Component,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pochaman","family":"Watcharapichat","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Medicine, Chiangrai Regional Hospital, Chiangrai,3 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duangporn","family":"Phulsuksombati","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Medicine, Chiangrai Regional Hospital, Chiangrai,3 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1086\/516281","article-title":"Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya.","volume":"26","author":"Anderson S. L.","year":"1998","unstructured":"Anderson S. L. Oloo A. J. Gordon D. M. Ragama O. B. Aleman G. M. Berman J. D. Tang D. B. Dunne M. W. Shanks G. D. Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. Clin. Infect. Dis. 26 1998 146 150","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1086\/517742","article-title":"Azithromycin therapy for scrub typhus during pregnancy.","volume":"27","author":"Choi E.","year":"1998","unstructured":"Choi E. Hyunjoo P. Azithromycin therapy for scrub typhus during pregnancy. Clin. Infect. Dis. 27 1998 1538 1539","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_1_4_2","unstructured":"Kawamura\n              A.\n              Tanaka\n              H.\n              Tamura\n              A. R. tsutsugamushi infection and pregnancy.\n          Tsutsugamushi disease.\n              Kawamura\n              A.\n              Tanaka\n              H.\n              Tamura\n              A.\n          1995\n          University of Tokyo Press\n          Tokyo Japan"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.2.285"},{"key":"e_1_3_1_6_2","first-page":"44","article-title":"Three cases of tsutsugamushi disease successfully treated with clarithromycin.","volume":"40","author":"Miura N.","year":"1997","unstructured":"Miura N. Kudoh Y. Osabe M. Shimoda T. Kohno S. Hara K. Three cases of tsutsugamushi disease successfully treated with clarithromycin. Acta Med. Nagasaki 40 1997 44 47","journal-title":"Acta Med. Nagasaki"},{"key":"e_1_3_1_7_2","unstructured":"National Institutes of Health\n          Guide for the care and use of laboratory animals. National Institutes of Health publication no. 86-23 1985.\n          1985\n          National Institutes of Health\n          Bethesda Md"},{"key":"e_1_3_1_8_2","first-page":"163","article-title":"Antibiotici in gravidanza.","volume":"71","author":"Pecorari D.","year":"1990","unstructured":"Pecorari D. Bellone F. Antibiotici in gravidanza. G. Clin. Med. 71 1990 163 170","journal-title":"G. Clin. Med."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199711000-00013"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(97)01020-X"},{"key":"e_1_3_1_11_2","first-page":"794","article-title":"Scrub typhus in the Western Pacific region.","volume":"26","author":"Silpapojakul K.","year":"1997","unstructured":"Silpapojakul K. Scrub typhus in the Western Pacific region. Ann. Acad. Med. Singap. 26 1997 794 800","journal-title":"Ann. Acad. Med. Singap."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.11.2406"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1542\/peds.89.5.965","article-title":"Neonatal scrub typhus: a case report.","volume":"89","author":"Wang C. L.","year":"1992","unstructured":"Wang C. L. Yang K. D. Cheung S. N. Chu M. L. Neonatal scrub typhus: a case report. Pediatrics 89 1992 965 968","journal-title":"Pediatrics"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/clinids\/18.4.624","article-title":"Life-threatening scrub typhus in a traveler returning from Thailand.","volume":"18","author":"Watt G.","year":"1994","unstructured":"Watt G. Strickman D. Life-threatening scrub typhus in a traveler returning from Thailand. Clin. Infect. Dis. 18 1994 624 626","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(96)02501-9","article-title":"Scrub typhus infections poorly responsive to antibiotics in northern Thailand.","volume":"348","author":"Watt G.","year":"1996","unstructured":"Watt G. Chouriyagune C. Ruangweerayud R. Watcharapichat P. Phulsuksombati D. Jongsakul K. Teja-Isavadharm P. Bodhidatta D. Corcoran K. D. Dasch G. A. Strickman D. Scrub typhus infections poorly responsive to antibiotics in northern Thailand. Lancet 348 1996 86 89","journal-title":"Lancet"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1086\/517813","article-title":"Prospective evaluation of a dot blot immunoassay for the rapid diagnosis of scrub typhus.","volume":"177","author":"Watt G.","year":"1998","unstructured":"Watt G. Strickman D. Kantipong P. Jongsakul K. Paxton H. Prospective evaluation of a dot blot immunoassay for the rapid diagnosis of scrub typhus. J. Infect. Dis. 177 1998 800 802","journal-title":"J. Infect. Dis."},{"key":"e_1_3_1_17_2","unstructured":"Watt G. Unpublished data."},{"key":"e_1_3_1_18_2","unstructured":"Wisseman\n              C. L.\n          Rickettsial infections\n          Hunter\u2019s tropical medicine\n          7th ed.\n              Strickland\n              G. T.\n          1991\n          265\n          W. B. Saunders Company\n          Philadelphia Pa"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.11.2817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.11.2817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:54:07Z","timestamp":1645458847000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.11.2817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["10.1128\/AAC.43.11.2817"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.11.2817","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]},"assertion":[{"value":"1999-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}