{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:03:49Z","timestamp":1784653429869,"version":"3.55.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The interaction between fluconazole (Flu) and amphotericin B (AmB) was evaluated in a murine model of systemic candidiasis for one Flu-susceptible strain (MIC, 0.5 \u03bcg\/ml), two strains with intermediate Flu resistance (Flu mid-resistant strains) (MIC, 64 and 128 \u03bcg\/ml), and one highly Flu-resistant strain (MIC, 512 \u03bcg\/ml) of\n            <jats:italic>Candida albicans<\/jats:italic>\n            . Differences in fungal densities in kidneys of infected mice after 24 h of therapy and in survival rates at 62 days of mice treated with an antifungal drug or a combination of antifungal drugs for 4 days were compared. For the Flu-susceptible and Flu mid-resistant strains, the combination of Flu and AmB was antagonistic, as shown by both quantitative culture results and survival. The interaction was additive for the highly Flu-resistant strain. These results suggest that the combination of Flu and AmB should be used with caution in infections due to fungi that are usually susceptible to both antifungal agents and as empirical antifungal drug therapy.\n          <\/jats:p>","DOI":"10.1128\/aac.43.12.2841","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:03Z","timestamp":1539045243000},"page":"2841-2847","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Interaction between Fluconazole and Amphotericin B in Mice with Systemic Infection Due to Fluconazole-Susceptible or -Resistant Strains of\n            <i>Candida albicans<\/i>"],"prefix":"10.1128","volume":"43","author":[{"given":"Arnold","family":"Louie","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases1 and"},{"name":"<!--label omitted: 2-->Wadsworth Center, New York State Department of Health, Albany, New York 122012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Banerjee","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases1 and"},{"name":"<!--label omitted: 2-->Wadsworth Center, New York State Department of Health, Albany, New York 122012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Drusano","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases1 and"},{"name":"<!--label omitted: 3-->Clinical Pharmacology,3 Department of Medicine, Albany Medical College, Albany, New York 12208, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Shayegani","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Wadsworth Center, New York State Department of Health, Albany, New York 122012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Miller","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases1 and"},{"name":"<!--label omitted: 3-->Clinical Pharmacology,3 Department of Medicine, Albany Medical College, Albany, New York 12208, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2201"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/clinids\/23.5.964","article-title":"Management of invasive candidal infections: results of a prospective, randomized, multicenter study of fluconazole versus amphotericin B and review of the literature.","volume":"23","author":"Anaissie E. J.","year":"1996","unstructured":"Anaissie E. J. Darouiche R. O. Abi-Said D. Uzun O. Mera J. Gentry L. O. Williams T. Kontoyiannis D. P. Karl C. L. Bodey G. P. Management of invasive candidal infections: results of a prospective, randomized, multicenter study of fluconazole versus amphotericin B and review of the literature. Clin. Infect. Dis. 23 1996 964 972","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_5_2","unstructured":"Banerjee\n              P.\n              Liu\n              Q.-F.\n              Louie\n              A.\n              Shayegani\n              M.\n              Taber\n              H.\n              Drusano\n              G.\n              Miller\n              M.\n          Comparison of checkerboard isobolograms and computer generated 3D-plots for evaluation of the in-vitro interactions between antifungal drugs abstr. C-252a\n          Abstracts of the 97th General Meeting of the American Society for Microbiology.\n          1997\n          164\n          American Society for Microbiology\n          Washington D.C."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.12.4.550"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.5.1247"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.2.183"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM199401273300407","article-title":"Oral azole drugs as systemic antifungal therapy.","volume":"330","author":"Como J. A.","year":"1994","unstructured":"Como J. A. Dismukes W. E. Oral azole drugs as systemic antifungal therapy. N. Engl. J. Med. 330 1994 263 272","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.29.4.584"},{"key":"e_1_3_2_11_2","first-page":"877","article-title":"Fluconazole. 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Approved standard M27-A.\n          1995\n          National Committee for Clinical Laboratory Standards\n          Villanova Pa"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/jac\/27.4.491","article-title":"Interactions in vitro between polyenes and imidazoles against yeast.","volume":"27","author":"Petrou M. A.","year":"1991","unstructured":"Petrou M. A. Rogers T. R. Interactions in vitro between polyenes and imidazoles against yeast. J. Antimicrob. Chemother. 27 1991 491 506","journal-title":"J. Antimicrob. 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