{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:04:25Z","timestamp":1792739065298,"version":"4.5.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The intravenous injection of vancomycin sometimes causes anaphylactoid reactions, in which histamine release may play a major role. These reactions are more frequently manifested when vancomycin is injected into anesthetized patients. We examined the vancomycin-induced histamine release and the interaction of vancomycin with muscle relaxants or opioid in rats. In an in vitro study with rat peritoneal mast cells, treatment with vancomycin at concentrations of greater than 1.25 mM produced significant histamine release. Tubocurarine, vecuronium, pancuronium, succinylcholine, and morphine up to concentrations of 0.25, 1, 5, 30, and 5 mM, respectively, produced no significant histamine release. However, the nonsignificant histamine release induced by 0.5 mM vancomycin was clearly enhanced by combining vancomycin with any of these agents. In the in vivo study, the intravenous injection of vancomycin significantly increased the plasma histamine levels in rats when vancomycin was injected at 200 mg\/kg of body weight (63.2 \u00b1 34.0 ng\/ml [mean \u00b1 standard deviation]) but not when it was injected at 100 mg\/kg (30.8 \u00b1 20.2 ng\/ml) compared with that in the saline-treated rats (22.5 \u00b1 11.4 ng\/ml). Although the subcutaneous administration of morphine (10 mg\/kg) never increased the plasma histamine levels, the intravenous injection of vancomycin (100 mg\/kg) 30 min after this morphine treatment markedly increased the plasma histamine levels (56.0 \u00b1 26.9 ng\/ml). These findings provide experimental evidence that the combination of muscle relaxants or an opioid with vancomycin may increase the risk of anaphylactoid reactions by enhancing the release of histamine.<\/jats:p>","DOI":"10.1128\/aac.43.12.2881","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:34:03Z","timestamp":1539030843000},"page":"2881-2884","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Potentiation of Vancomycin-Induced Histamine Release by Muscle Relaxants and Morphine in Rats"],"prefix":"10.1128","volume":"43","author":[{"given":"Hideki","family":"Shuto","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Sueyasu","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Otsuki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Hara","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryozo","family":"Oishi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.7326\/0003-4819-102-5-723","article-title":"Vancomycin and red necks.","volume":"102","author":"Ackerman B. 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