{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:57:01Z","timestamp":1791262621553,"version":"4.1.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Current therapy for leishmaniasis is unsatisfactory. Efficacious and safe oral therapy would be ideal. We examined the efficacy of SCH 56592, an investigational triazole antifungal agent, against cutaneous infection with\n            <jats:italic>Leishmania amazonensis<\/jats:italic>\n            and visceral infection with\n            <jats:italic>Leishmania donovani<\/jats:italic>\n            in BALB\/c mice. Mice were infected in the ear pinna and tail with\n            <jats:italic>L. amazonensis<\/jats:italic>\n            promastigotes and were treated with oral SCH 56592 or intraperitoneal amphotericin B for 21 days. At doses of 60 and 30 mg\/kg\/day, SCH 56592 was highly efficacious in treating cutaneous disease, and at a dose of 60 mg\/kg\/day, it was superior to amphotericin B at a dose of 1 mg\/kg\/day. The means of tail lesion sizes were 0.32 \u00b1 0.12, 0.11 \u00b1 0.06, 0.17 \u00b1 0.07, and 0.19 \u00b1 0.08 mm for controls, SCH 56592 at 60 and 30 mg\/kg\/day, and amphotericin B recipients, respectively (\n            <jats:italic>P<\/jats:italic>\n            = 0.0003, 0.005, and 0.01, respectively). Parasite burden in draining lymph nodes confirmed these efficacy findings. In visceral leishmaniasis due to\n            <jats:italic>L. donovani<\/jats:italic>\n            infection, mice treated with SCH 56592 showed a 0.5- to 1-log-unit reduction in parasite burdens in the liver and the spleen compared to untreated mice. Amphotericin B at 1 mg\/kg\/day was superior to SCH 56592 in the treatment of visceral infection, with a 2-log-unit reduction in parasite burdens in both the liver and spleen. These studies indicate very good activity of SCH 56592 against cutaneous leishmaniasis due to\n            <jats:italic>L. amazonensis<\/jats:italic>\n            infection and, to a lesser degree, against visceral leishmaniasis due to\n            <jats:italic>L. donovani<\/jats:italic>\n            infection in susceptible BALB\/c mice.\n          <\/jats:p>","DOI":"10.1128\/aac.43.12.2910","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:03Z","timestamp":1539045243000},"page":"2910-2914","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Efficacy of the Triazole SCH 56592 against\n            <i>Leishmania amazonensis<\/i>\n            and\n            <i>Leishmania donovani<\/i>\n            in Experimental Murine Cutaneous and Visceral Leishmaniases"],"prefix":"10.1128","volume":"43","author":[{"given":"Hail M.","family":"Al-Abdely","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Medical Service, Audie Murphy Veterans Administration Hospital,1 and"},{"name":"<!--label omitted: 2-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,2San Antonio, Texas 78284, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Medical Service, Audie Murphy Veterans Administration Hospital,1 and"},{"name":"<!--label omitted: 2-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,2San Antonio, Texas 78284, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Loebenberg","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Schering-Plough Research Institute, Kenilworth, New Jersey 078333"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Melby","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Medical Service, Audie Murphy Veterans Administration Hospital,1 and"},{"name":"<!--label omitted: 2-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,2San Antonio, Texas 78284, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2542"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.2.298"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/24.4.684"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0166-6851(86)90145-3","article-title":"Effects of ketoconazole on sterol biosynthesis by Leishmania mexicana mexicana amastigotes in murine macrophage tumor cells.","volume":"20","author":"Berman J. D.","year":"1986","unstructured":"Berman J. D. Goad L. J. Beach D. H. Holz G. G. Jr. Effects of ketoconazole on sterol biosynthesis by Leishmania mexicana mexicana amastigotes in murine macrophage tumor cells. Mol. Biochem. Parasitol. 20 1986 85 92","journal-title":"Mol. Biochem. Parasitol."},{"key":"e_1_3_2_6_2","first-page":"198","article-title":"Failure of oral ketoconazole to cure cutaneous ulcers caused by Leishmania braziliensis.","volume":"38","author":"Dan M.","year":"1986","unstructured":"Dan M. Verner E. el-On J. Zuckerman F. Michaeli D. Failure of oral ketoconazole to cure cutaneous ulcers caused by Leishmania braziliensis. Cutis 38 1986 198 199","journal-title":"Cutis"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0020-7519(96)00128-2","article-title":"Itraconazole and leishmaniasis: a randomised double-blind trial in cutaneous disease.","volume":"26","author":"Dogra J.","year":"1996","unstructured":"Dogra J. Saxena V. N. Itraconazole and leishmaniasis: a randomised double-blind trial in cutaneous disease. Int. J. Parasitol. 26 1996 1413 1415","journal-title":"Int. J. Parasitol."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.1.83"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/clind\/16.3.397","article-title":"Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in a renal transplant recipient after the occurrence of pancreatitis due to stibogluconate.","volume":"16","author":"Halim M. A.","year":"1993","unstructured":"Halim M. A. Alfurayh O. Kalin M. E. Dammas S. al-Eisa A. Damanhouri G. Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in a renal transplant recipient after the occurrence of pancreatitis due to stibogluconate. Clin. Infect. Dis. 16 1993 397 399","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90406-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890310070009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1124"},{"key":"e_1_3_2_13_2","first-page":"392","article-title":"The efficacy and safety of ketoconazole in visceral leishmaniasis.","volume":"71","author":"Rashid J. R.","year":"1994","unstructured":"Rashid J. R. Wasunna K. M. Gachihi G. S. Nyakundi P. M. Mbugua J. Kirigi G. The efficacy and safety of ketoconazole in visceral leishmaniasis. East Afr. Med. J. 71 1994 392 395","journal-title":"East Afr. Med. J."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90476-X"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2165\/00003495-199040020-00002","article-title":"Therapy and prophylaxis of systemic protozoan infections.","volume":"40","author":"Van Voorhis W. C.","year":"1990","unstructured":"Van Voorhis W. C. Therapy and prophylaxis of systemic protozoan infections. Drugs 40 1990 176 202","journal-title":"Drugs"},{"key":"e_1_3_2_16_2","first-page":"644","article-title":"American cutaneous and mucocutaneous leishmaniasis","author":"Walton B. C.","year":"1987","unstructured":"Walton B. C. American cutaneous and mucocutaneous leishmaniasis The leishmaniases in biology and medicine Peters W. Killick-Kendrick R. II 1987 644 Academic Press London, United Kingdom","journal-title":"The leishmaniases in biology and medicine"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.12.2910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.12.2910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:52:22Z","timestamp":1645458742000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.12.2910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["10.1128\/AAC.43.12.2910"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.12.2910","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]},"assertion":[{"value":"1999-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}