{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:41:21Z","timestamp":1784191281688,"version":"3.55.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Twelve SHV-type extended-spectrum \u03b2-lactamase (ESBL)-producing\n            <jats:italic>Escherichia coli lac<\/jats:italic>\n            mutant isolates were recovered in October 1997 from 11 patients of the neonatal ward in a Warsaw hospital. The outbreak was clonal; however, some of the isolates expressed a much higher level of resistance to several \u03b2-lactam antibiotics, including expanded-spectrum cephalosporins. This phenotype has been attributed to \u03b2-lactamase hyperproduction correlating with the multiplication of ESBL gene copies, as was demonstrated for representative isolates.\n          <\/jats:p>","DOI":"10.1128\/aac.43.2.393","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:13Z","timestamp":1539045253000},"page":"393-396","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Diversification of\n            <i>Escherichia coli<\/i>\n            Expressing an SHV-Type Extended-Spectrum \u03b2-Lactamase (ESBL) during a Hospital Outbreak: Emergence of an ESBL-Hyperproducing Strain Resistant to Expanded-Spectrum Cephalosporins"],"prefix":"10.1128","volume":"43","author":[{"given":"Andrzej","family":"Pa\u0142ucha","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Sera and Vaccines Central Research Laboratory, 00-725 Warsaw,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mikiewicz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Health Care Center Praga-Po\u0301\u0142noc, 03-719 Warsaw,2 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Gniadkowski","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Sera and Vaccines Central Research Laboratory, 00-725 Warsaw,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01704610"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.12.2439"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.7.3219"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.2.913-916.1987"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.2.358-363.1996"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.514"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.4.827"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1099\/00221287-137-12-2681","article-title":"An IS1-like element is responsible for high-level synthesis of extended-spectrum \u03b2-lactamase TEM-6 in Enterobacteriaceae.","volume":"137","author":"Goussard S.","year":"1991","unstructured":"Goussard S. Sougakoff W. Mabilat C. Bauernfeind A. Courvalin P. An IS1-like element is responsible for high-level synthesis of extended-spectrum \u03b2-lactamase TEM-6 in Enterobacteriaceae. J. Gen. Microbiol. 137 1991 2681 2687","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_10_2","unstructured":"Hryniewicz\n              W.\n              Trzci\u0144ski\n              K.\n              Nowak\n              J.\n              Giffing\n              I.\n          National survey of the susceptibility of clinically important bacterial pathogens isolated in Poland in 1995 to piperacillin\/tazobactam and other antimicrobial agents.\n          Presented at the 8 th International Congress of Bacteriology and Applied Microbiology Division International Union of Microbiological Societies Jerusalem Israel 18 to 23 September 1996\n          1996"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.4.867"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-619X(90)90041-A"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-88-1-169"},{"key":"e_1_3_2_14_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A4.\n          1997\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.943"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1128\/AAC.1.4.283","article-title":"Novel method for detection of \u03b2-lactamases by using a chromogenic cephalosporin substrate.","volume":"1","author":"O\u2019Callaghan C. H.","year":"1972","unstructured":"O\u2019Callaghan C. H. Morris A. Kirby S. M. Shingler A. H. Novel method for detection of \u03b2-lactamases by using a chromogenic cephalosporin substrate. Antimicrob. Agents Chemother. 1 1972 283 288","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_17_2","first-page":"229","article-title":"Characterization of a novel SHV \u03b2-lactamase variant that resembles the SHV-5 enzyme.","volume":"139","author":"Prinarakis E. E.","year":"1996","unstructured":"Prinarakis E. E. Tzelepi E. Gazouli M. Mentis A. F. Tzouvelekis L. S. Characterization of a novel SHV \u03b2-lactamase variant that resembles the SHV-5 enzyme. FEMS Microbiol. Lett. 139 1996 229 234","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/BF01975047","article-title":"Synergistic effect of dosage and bacterial inoculum in TEM-1 mediated antibiotic resistance.","volume":"7","author":"Reguera J. A.","year":"1988","unstructured":"Reguera J. A. Baquero F. Perez-Diaz J. C. Martinez J. L. Synergistic effect of dosage and bacterial inoculum in TEM-1 mediated antibiotic resistance. Eur. J. Clin. Microbiol. Infect. Dis. 7 1988 778 779","journal-title":"Eur. J. Clin. Microbiol. Infect. 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