{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:47:34Z","timestamp":1768888054829,"version":"3.49.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activity of imipenem against\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            HUS-3 decreased by 16 times in the presence of substances eluted from siliconized latex urinary catheters (SLUCs). SLUCs did not inactivate imipenem or increase \u03b2-lactamase activity. The outer membrane of\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            HUS-3 grown in the presence of eluate lacked an OprD-like protein and expressed a new 50-kDa protein. The decreased activity of imipenem against\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            in the presence of SLUCs is related to the loss of an OprD-like protein and the expression of a new outer membrane protein.\n          <\/jats:p>","DOI":"10.1128\/aac.43.2.397","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:13Z","timestamp":1539045253000},"page":"397-399","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Resistance of\n            <i>Pseudomonas aeruginosa<\/i>\n            to Imipenem Induced by Eluates from Siliconized Latex Urinary Catheters Is Related to Outer Membrane Protein Alterations"],"prefix":"10.1128","volume":"43","author":[{"given":"Luis","family":"Marti\u0301nez-Marti\u0301nez","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, School of Medicine, University of Seville,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Pascual","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, School of Medicine, University of Seville,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u0301a","family":"del Carmen Conejo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, School of Medicine, University of Seville,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Picabea","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Forensic Science Institute,2 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelio J.","family":"Perea","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, School of Medicine, University of Seville,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.13.3825-3831.1994"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.9.1757"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1046\/j.1365-2958.1997.2281594.x","article-title":"Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.","volume":"23","author":"K\u00f6hler T.","year":"1997","unstructured":"K\u00f6hler T. Mich\u00e9a-Hamzehpour M. Henze U. Gotoh N. Curty L. K. Pech\u00e8re J.-C. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol. Microbiol. 23 1997 343 354","journal-title":"Mol. Microbiol."},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.9.2046"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0732-8893(91)90078-T","article-title":"Effect of a siliconized latex urinary catheter on bacterial adherence and human neutrophil activity.","volume":"14","author":"L\u00f3pez-L\u00f3pez G.","year":"1991","unstructured":"L\u00f3pez-L\u00f3pez G. Pascual A. Mart\u0131\u0301nez-Mart\u0131\u0301nez L. Perea E. J. Effect of a siliconized latex urinary catheter on bacterial adherence and human neutrophil activity. Diagn. Microbiol. Infect. Dis. 14 1991 1 6","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(90)90003-7"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1099\/00222615-34-1-7","article-title":"Kinetics of adherence of mucoid and non-mucoid Pseudomonas aeruginosa to plastic catheters.","volume":"34","author":"Mart\u0131\u0301nez-Mart\u0131\u0301nez L.","year":"1991","unstructured":"Mart\u0131\u0301nez-Mart\u0131\u0301nez L. Pascual A. Perea E. J. Kinetics of adherence of mucoid and non-mucoid Pseudomonas aeruginosa to plastic catheters. J. Med. Microbiol. 34 1991 7 12","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_1_11_2","unstructured":"Mart\u0131\u0301nez-Mart\u0131\u0301nez\n              L.\n              Pascual\n              A.\n              Conejo\n              M. C.\n              Picabea\n              L.\n              Perea\n              E. J.\n          Siliconized latex urinary catheters (SLUC) induce imipenem (IMP) resistance and outer membrane proteins (OMP) alterations in P. aeruginosa abstr. C-40\n          Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1997\n          52\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.3.645"},{"key":"e_1_3_1_13_2","first-page":"273","article-title":"Multiantibiotic resistance caused by active drug extrusion in Pseudomonas aeruginosa and other gram-negative bacteria.","volume":"13","author":"Nakae T.","year":"1997","unstructured":"Nakae T. Multiantibiotic resistance caused by active drug extrusion in Pseudomonas aeruginosa and other gram-negative bacteria. Microbiol. SEM 13 1997 273 284","journal-title":"Microbiol. 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