{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:17:13Z","timestamp":1790911033617,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n CL 188,624, CL 190,294, and CL 191,121 are novel aminomethyl tetrahydrofuranyl (THF)-1\u03b2-methylcarbapenems. The in vitro antibacterial activities of these THF carbapenems were evaluated and compared with those of biapenem, imipenem, and meropenem against 554 recent clinical isolates obtained from geographically distinct medical centers across North America. The antibacterial activities of the THF carbapenems were equivalent to that of biapenem, and the THF carbapenems were slightly more active than imipenem and less active than meropenem against most of the members of the family\n Enterobacteriaceae<\/jats:italic>\n but lacked significant activity against\n Pseudomonas<\/jats:italic>\n isolates. In general, CL 191,121 was two- to fourfold more active than CL 188,624 and CL 190,294 against the staphylococcal and enterococcal isolates tested. CL 191,121 was twofold less active than imipenem against methicillin-susceptible staphylococci and was as activity as imipenem against\n Enterococcus faecalis<\/jats:italic>\n isolates. Biapenem and meropenem were two- and fourfold less active than CL 191,121, respectively, against the methicillin-susceptible staphylococci and\n E. faecalis<\/jats:italic>\n . All the carbapenems displayed equivalent good activities against the streptococci. Biapenem was slightly more active than the other carbapenems against\n Bacteroides fragilis<\/jats:italic>\n isolates. Time-kill curve studies demonstrated that the THF carbapenems were bactericidal in 6 h against\n Escherichia coli<\/jats:italic>\n and\n Staphylococcus aureus<\/jats:italic>\n isolates. The postantibiotic effect exerted by CL 191,121 was comparable to or slightly longer than that of imipenem against isolates of\n S. aureus<\/jats:italic>\n ,\n E. coli<\/jats:italic>\n , and\n Klebsiella pneumoniae.<\/jats:italic>\n <\/jats:p>","DOI":"10.1128\/aac.43.3.454","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:19Z","timestamp":1539045259000},"page":"454-459","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["In Vitro Activities of Aminomethyl-Substituted Analogs of Novel Tetrahydrofuranyl Carbapenems"],"prefix":"10.1128","volume":"43","author":[{"given":"William J.","family":"Weiss","sequence":"first","affiliation":[{"name":"Infectious Disease Research Section, Antimicrobial Chemotherapy, Wyeth-Ayerst Research, Pearl River, New York 10965"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Section, Antimicrobial Chemotherapy, Wyeth-Ayerst Research, Pearl River, New York 10965"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilda V.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Section, Antimicrobial Chemotherapy, Wyeth-Ayerst Research, Pearl River, New York 10965"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-I","family":"Lin","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Section, Antimicrobial Chemotherapy, Wyeth-Ayerst Research, Pearl River, New York 10965"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayota","family":"Bitha","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Section, Antimicrobial Chemotherapy, Wyeth-Ayerst Research, Pearl River, New York 10965"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond T.","family":"Testa","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Section, Antimicrobial Chemotherapy, Wyeth-Ayerst Research, Pearl River, New York 10965"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Bush\n K.\n Bhachech\n N.\n Yang\n Y.\n Weiss\n W.\n Lin\n Y.\n Testa\n R.\n Tally\n F.\n Binding to penicillin-binding proteins (PBPs) and permeability of novel THF carbapenems abstr. F76\n Program and abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n 1994\n 128\n American Society for Microbiology\n Washington D.C"},{"key":"e_1_3_2_3_2","unstructured":"Craig\n W.\n Gudmundsson\n S.\n The postantibiotic effect\n Antibiotics in laboratory medicine\n 2nd ed.\n Lorian\n V.\n 1986\n 515\n 536\n The Williams & Wilkins Co.\n Baltimore Md"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.12.2652"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1021\/jm00389a018","article-title":"Inhibition of the mammalian \u03b2-lactamase renal dipeptidase by (Z) -2-(acyclamido)-3-substituted-propenoic acids.","volume":"30","author":"Graham D.","year":"1987","unstructured":"Graham D. Ashton W. Barash L. Canning L. Chen A. Springer J. Rogers E. Inhibition of the mammalian \u03b2-lactamase renal dipeptidase by (Z) -2-(acyclamido)-3-substituted-propenoic acids. J. Med. 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Pharmacotherapy 12 6 Pt 2 1992 86S 93S","journal-title":"Pharmacotherapy"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.12.2756"},{"key":"e_1_3_2_17_2","unstructured":"National Committee for Clinical Laboratory Standards\n Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically\n 17. Approved standard M7-A4\n 1997\n National Committee for Clinical Laboratory Standards\n Wayne Pa"},{"key":"e_1_3_2_18_2","unstructured":"National Committee for Clinical Laboratory Standards\n Methods for determining bactericidal activity of antimicrobial agents. Proposed guideline M26-T.\n 1992\n National Committee for Clinical Laboratory Standards\n Wayne Pa"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.7.1418"},{"key":"e_1_3_2_20_2","unstructured":"Pelak\n B.\n Gerckens\n L.\n Scott\n P.\n Gill\n C.\n Pacholok\n C.\n Lynch\n L.\n Dorso\n H.\n Kohler\n J.\n Shungu\n D.\n Rosen\n H.\n Kropp\n H.\n Antibacterial profile of L-749 345 (ZD-4433) a new potent 1-\u03b2-methyl carbapenem abstr. 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J.\n 1991\n 1161\n 1162\n American Society for Microbiology\n Washington D.C"},{"key":"e_1_3_2_25_2","unstructured":"Sutter\n V.\n Citron\n D.\n Edelstein\n M.\n Finegold\n S.\n Wadsworth anaerobic bacteriology manual\n 1985\n 30\n 67\n Star Publishing Co.\n Belmont Calif"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.6.1260"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.94"},{"key":"e_1_3_2_28_2","unstructured":"Weiss\n W.\n Yang\n Y.\n Petersen\n P.\n Shelofsky\n A.\n Bush\n K.\n Jacobus\n N.\n Bitha\n P.\n Lin\n Y.\n Testa\n R.\n Tally\n F.\n In vitro activity and \u03b2-lactamase stability of novel THF carbapenems abstr. F74\n Program and abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n 1994\n 128\n American Society for Microbiology\n Washington D.C"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.6.1387"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.3.454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.3.454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:10:13Z","timestamp":1645459813000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.3.454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["10.1128\/AAC.43.3.454"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.3.454","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]},"assertion":[{"value":"1998-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}