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In this isolate,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>IMP<\/jats:sub>\n            was carried on a 36-kb plasmid, and similar to the identical alleles found in\n            <jats:italic>Serratia marcescens<\/jats:italic>\n            and\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            clinical isolates, it was located on a mobile gene cassette inserted into an integron. The entire structure of this integron, named In31, was determined. In31 is a class 1 element belonging to the same group of defective transposon derivatives that originated from Tn\n            <jats:italic>402<\/jats:italic>\n            -like ancestors such as In0, In2, and In5. The general structure of In31 appeared to be most closely related to that of In5 from pSCH884, suggesting a recent common phylogeny for these two elements. In In31, the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>IMP<\/jats:sub>\n            cassette is the first of an array of five gene cassettes that also includes an\n            <jats:italic>aacA4<\/jats:italic>\n            cassette and three original cassettes that have never been described in other integrons. The novel cassettes carry, respectively, (i) a new chloramphenicol acetyltransferase-encoding allele of the\n            <jats:italic>catB<\/jats:italic>\n            family, (ii) a\n            <jats:italic>qac<\/jats:italic>\n            allele encoding a new member of the small multidrug resistance family of proteins, and (iii) an open reading frame encoding a protein of unknown function. All the resistance genes carried on cassettes inserted in In31 were found to be functional in decreasing the in vitro susceptibilities of host strains to the corresponding antimicrobial agents.\n          <\/jats:p>","DOI":"10.1128\/aac.43.4.890","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:41Z","timestamp":1539045281000},"page":"890-901","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":138,"title":["Structure of In31, a\n            <i>bla<\/i>\n            <sub>IMP<\/sub>\n            -Containing\n            <i>Pseudomonas aeruginosa<\/i>\n            Integron Phyletically Related to In5, Which Carries an Unusual Array of Gene Cassettes"],"prefix":"10.1128","volume":"43","author":[{"given":"Nezha","family":"Laraki","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire d\u2019Enzymologie &amp; Centre d\u2019Inge\u0301nierie des Prote\u0301ines, Institut de Chimie, Universite\u0301 de Lie\u0300ge, B-4000 Lie\u0300ge, Belgium,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreno","family":"Galleni","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire d\u2019Enzymologie &amp; Centre d\u2019Inge\u0301nierie des Prote\u0301ines, Institut de Chimie, Universite\u0301 de Lie\u0300ge, B-4000 Lie\u0300ge, Belgium,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Thamm","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire d\u2019Enzymologie &amp; Centre d\u2019Inge\u0301nierie des Prote\u0301ines, Institut de Chimie, Universite\u0301 de Lie\u0300ge, B-4000 Lie\u0300ge, Belgium,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Riccio","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Universita\u0300 di Siena, I-53100 Siena,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Amicosante","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Dipartimento di Scienze &amp; Technologie Biomediche, Universita\u0300 dell\u2019Aquila, I-67100 L\u2019Aquila, Italy3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Fre\u0300re","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire d\u2019Enzymologie &amp; Centre d\u2019Inge\u0301nierie des Prote\u0301ines, Institut de Chimie, Universite\u0301 de Lie\u0300ge, B-4000 Lie\u0300ge, Belgium,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Rossolini","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Universita\u0300 di Siena, I-53100 Siena,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.7.1612"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.4.1248-1257.1992"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.15.4429-4437.1996"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.3.686"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.5.1574-1585.1992"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01467.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01667.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.155"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.1Part1.387"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.7.1456"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01963.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.158.3.1115-1121.1984"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/nar\/9.1.213-b","article-title":"Codon catalog usage is a genome strategy modulated for gene expressivity.","volume":"9","author":"Grantham R.","year":"1981","unstructured":"Grantham R. 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