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Although the drugs were not very active against other gram-negative bacteria, the MICs at which 90% of isolates are inhibited for these drugs were lower (0.002 and 0.008 \u03bcg\/ml, respectively) than those of amoxicillin and rifampin for\n            <jats:italic>H. pylori<\/jats:italic>\n            . Time-kill studies revealed that the bactericidal activities of these agents were due to cell lysis. The results presented here indicate that these new rifamycin derivatives may be useful for the eradication of\n            <jats:italic>H. pylori<\/jats:italic>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/aac.43.5.1072","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:57Z","timestamp":1539045297000},"page":"1072-1076","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["In Vitro Anti-\n            <i>Helicobacter pylori<\/i>\n            Activities of New Rifamycin Derivatives, KRM-1648 and KRM-1657"],"prefix":"10.1128","volume":"43","author":[{"given":"Junko K.","family":"Akada","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsunori","family":"Shirai","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Fujii","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->KANEKA Corporation, Takasago Research Laboratories, Takasago, Hyogo 676-8688,2 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiwamu","family":"Okita","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->First Department of Internal Medicine,3 Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2331-2335.1996"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.8.1859"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/clind\/15.3.386","article-title":"Helicobacter pylori: its role in disease.","volume":"15","author":"Blaser M. 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