{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:36:01Z","timestamp":1791246961143,"version":"4.1.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n The in vitro and in vivo activities of T-3811ME, a novel des-F(6)-quinolone, were evaluated in comparison with those of some fluoroquinolones, including a newly developed one, trovafloxacin. T-3811, a free base of T-3811ME, showed a wide range of antimicrobial spectra, including activities against\n Chlamydia trachomatis<\/jats:italic>\n ,\n Mycoplasma pneumoniae<\/jats:italic>\n , and\n Mycobacterium tuberculosis<\/jats:italic>\n . In particular, T-3811 exhibited potent activity against various gram-positive cocci, with MICs at which 90% of the isolates are inhibited (MIC\n 90<\/jats:sub>\n s) of 0.025 to 6.25 \u03bcg\/ml. T-3811 was the most active agent against methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n and streptococci, including penicillin-resistant\n Streptococcus pneumoniae<\/jats:italic>\n (PRSP). T-3811 also showed potent activity against quinolone-resistant gram-positive cocci with GyrA and ParC (GrlA) mutations. The activity of T-3811 against members of the family\n Enterobacteriaceae<\/jats:italic>\n and nonfermentative gram-negative rods was comparable to that of trovafloxacin. In common with other fluoroquinolones, T-3811 was highly active against\n Haemophilus influenzae<\/jats:italic>\n ,\n Moraxella catarrhalis<\/jats:italic>\n , and\n Legionella<\/jats:italic>\n sp., with MIC\n 90<\/jats:sub>\n s of 0.0125 to 0.1 \u03bcg\/ml. T-3811 showed a potent activity against anaerobic bacteria, such as\n Bacteroides fragilis<\/jats:italic>\n and\n Clostridium difficile<\/jats:italic>\n . T-3811 was the most active agent against\n C. trachomatis<\/jats:italic>\n (MIC, 0.008 \u03bcg\/ml) and\n M. pneumoniae<\/jats:italic>\n (MIC\n 90<\/jats:sub>\n , 0.0313 \u03bcg\/ml). The activity of T-3811 against\n M. tuberculosis<\/jats:italic>\n (MIC\n 90<\/jats:sub>\n , 0.0625 \u03bcg\/ml) was potent and superior to that of trovafloxacin. In experimental systemic infection with a GrlA mutant of\n S. aureus<\/jats:italic>\n and experimental pneumonia with PRSP in mice, T-3811ME showed excellent therapeutic efficacy in oral and subcutaneous administrations.\n <\/jats:p>","DOI":"10.1128\/aac.43.5.1077","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:57Z","timestamp":1539045297000},"page":"1077-1084","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":139,"title":["In Vitro and In Vivo Antimicrobial Activities of T-3811ME, a Novel Des-F(6)-Quinolone"],"prefix":"10.1128","volume":"43","author":[{"given":"Masahiro","family":"Takahata","sequence":"first","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Mitsuyama","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Yonezawa","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Araki","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yozo","family":"Todo","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinzaburo","family":"Minami","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Narita","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd., Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/39.suppl_2.1","article-title":"The chemistry and biological profile of trovafloxacin.","volume":"39","author":"Brightly K. 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