{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:39:29Z","timestamp":1761129569188},"reference-count":48,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Fifty-seven\n            <jats:italic>Salmonella enterica<\/jats:italic>\n            serotype Typhimurium (\n            <jats:italic>S. typhimurium<\/jats:italic>\n            ) isolates were collected from human patients in two French hospitals, Ho\u0302pital Antoine Be\u0301cle\u0300re (Clamart, France) and Ho\u0302pital Bice\u0302tre (Le Kremlin-Bice\u0302tre, France), between 1996 and 1997. Thirty of them (52 percent) were resistant to amino-, carbeni-, and ureidopenicillins, had reduced susceptibility to amoxicillin-clavulanic acid, were susceptible to cephalothin, and were resistant to sulfonamides, streptomycin, chloramphenicol, and tetracyclines. All these strains possessed a\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>PSE-1<\/jats:sub>\n            -like gene and were of phage type DT104. Ten of them were studied in more detail, which revealed that\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>PSE-1<\/jats:sub>\n            is located on the variable region of a class 1 integron. This integron was found to be chromosomally located, as was another class 1 integron containing\n            <jats:italic>aadA2<\/jats:italic>\n            , a streptomycin-spectinomycin resistance gene. The reduced susceptibility to amoxicillin-clavulanic acid (and to ticarcillin-clavulanic acid) may result from the high level of hydrolysis of the \u03b2-lactam rather than to the clavulanic acid resistance properties of PSE-1 in these clonally related\n            <jats:italic>S. typhimurium<\/jats:italic>\n            isolates.\n          <\/jats:p>","DOI":"10.1128\/aac.43.5.1098","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:34:57Z","timestamp":1539045297000},"page":"1098-1104","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Integron- and Carbenicillinase-Mediated Reduced Susceptibility to Amoxicillin-Clavulanic Acid in Isolates of Multidrug-Resistant\n            <i>Salmonella enterica<\/i>\n            Serotype Typhimurium DT104 from French Patients"],"prefix":"10.1128","volume":"43","author":[{"given":"Laurent","family":"Poirel","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, 94275 Le Kremlin-Bice\u0302tre,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Guibert","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital Antoine Be\u0301cle\u0300re, 92141 Clamart, and Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine Paris-Sud,2 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Bellais","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, 94275 Le Kremlin-Bice\u0302tre,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Naas","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital Antoine Be\u0301cle\u0300re, 92141 Clamart, and Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine Paris-Sud,2 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, 94275 Le Kremlin-Bice\u0302tre,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400056187"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.7.1612"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.5.1172"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/mdr.1997.3.351","article-title":"Involvement of a 70-kb plasmid of the epidemic Shigella dysenteriae type (Dt66) strains in drug-resistance, lipopolysaccharide synthesis and virulence.","volume":"3","author":"Datta S.","year":"1997","unstructured":"Datta S. Pal A. Basu S. Banerjee P. C. Involvement of a 70-kb plasmid of the epidemic Shigella dysenteriae type (Dt66) strains in drug-resistance, lipopolysaccharide synthesis and virulence. Microb. Drug. Resist. 3 1997 351 357","journal-title":"Microb. Drug. Resist."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.3.771"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/jac\/39.1.103","article-title":"Reduced susceptibility to co-amoxiclav in Escherichia coli,Salmonella typhimurium and Klebsiella pneumoniae isolated in Romania between 1985 and 1993.","volume":"39","author":"Espinasse F.","year":"1997","unstructured":"Espinasse F. Gheorghiu R. Poiata A. Labia R. Nicolas-Chanoine M. H. Reduced susceptibility to co-amoxiclav in Escherichia coli,Salmonella typhimurium and Klebsiella pneumoniae isolated in Romania between 1985 and 1993. J. Antimicrob. Chemother. 39 1997 103 106","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805073381901"},{"key":"e_1_3_2_10_2","first-page":"192","article-title":"Mobile gene cassettes and integrons moving antibiotic resistance genes in gram-negative bacteria.","volume":"207","author":"Hall R. M.","year":"1997","unstructured":"Hall R. M. Mobile gene cassettes and integrons moving antibiotic resistance genes in gram-negative bacteria. Ciba Found. Symp. 207 1997 192 205","journal-title":"Ciba Found. Symp."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.11.2428"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1365-2672.1997.00203.x","article-title":"Carbenicillin-hydrolysing penicillinase mediated by a plasmid of Proteus mirabilis and its relationship to the PSE-type enzymes of Pseudomonas aeruginosa.","volume":"83","author":"Ito Y.","year":"1997","unstructured":"Ito Y. Hirano T. Carbenicillin-hydrolysing penicillinase mediated by a plasmid of Proteus mirabilis and its relationship to the PSE-type enzymes of Pseudomonas aeruginosa. J. Appl. Microbiol. 83 1997 175 180","journal-title":"J. Appl. Microbiol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/jac\/22.5.597","article-title":"Distribution of \u03b2-lactamases and phenotype analysis in clinical strains of Acinetobacter calcoaceticus.","volume":"22","author":"Joly-Guillou M. L.","year":"1988","unstructured":"Joly-Guillou M. L. Vall\u00e9e E. Bergogne-B\u00e9r\u00e9zin E. Philippon A. Distribution of \u03b2-lactamases and phenotype analysis in clinical strains of Acinetobacter calcoaceticus. J. Antimicrob. Chemother. 22 1988 597 604","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0924-8579(96)00336-6","article-title":"Antimicrobial susceptibility and serogroups of Salmonella isolates from Riyadh, Saudi Arabia.","volume":"7","author":"Kambal A. M.","year":"1996","unstructured":"Kambal A. M. Antimicrobial susceptibility and serogroups of Salmonella isolates from Riyadh, Saudi Arabia. Int. J. Antimicrob. Chemother. 7 1996 265 269","journal-title":"Int. J. Antimicrob. Chemother."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/jac\/38.3.425","article-title":"Multi-drug resistant non-typhi salmonellae in Kenya.","volume":"38","author":"Kariuki S.","year":"1996","unstructured":"Kariuki S. Gilks C. Corkill J. Kimari J. Benea A. Waiyaki P. Hart C. A. Multi-drug resistant non-typhi salmonellae in Kenya. J. Antimicrob. Chemother. 38 1996 425 434","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1432-1033.1993.tb18324.x","article-title":"Site-directed mutagenesis of \u03b2-lactamase TEM-1. Investigating the potential role of specific residues on the activity of Pseudomonas-specific enzymes.","volume":"217","author":"Lenfant F.","year":"1993","unstructured":"Lenfant F. Petit A. Labia R. Maveyraud L. Samama J. P. Masson J. M. Site-directed mutagenesis of \u03b2-lactamase TEM-1. Investigating the potential role of specific residues on the activity of Pseudomonas-specific enzymes. Eur. J. Biochem. 217 1993 939 946","journal-title":"Eur. J. Biochem."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.185"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/jac\/28.6.877","article-title":"Antimicrobial susceptibilities and \u03b2-lactamase production of Hong Kong isolates of gastro-enteric salmonellae and Salmonella typhi.","volume":"28","author":"Ling J. M.","year":"1991","unstructured":"Ling J. M. Zhou G. M. Woo T. H. French G. L. Antimicrobial susceptibilities and \u03b2-lactamase production of Hong Kong isolates of gastro-enteric salmonellae and Salmonella typhi. J. Antimicrob. Chemother. 28 1991 877 885","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/jac\/5.4.349","article-title":"Plasmid-mediated \u03b2-lactamases of gram-negative bacteria: properties and distribution.","volume":"5","author":"Matthew M.","year":"1979","unstructured":"Matthew M. Plasmid-mediated \u03b2-lactamases of gram-negative bacteria: properties and distribution. J. Antimicrob. Chemother. 5 1979 349 358","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.149.2.700-707.1982"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.5.1200"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1093\/clinids\/8.Supplement_2.S172","article-title":"Resistance of Shigella,Salmonella and other selected enteric pathogens to antimicrobial agents.","volume":"8","author":"Murray B. E.","year":"1986","unstructured":"Murray B. E. Resistance of Shigella,Salmonella and other selected enteric pathogens to antimicrobial agents. Rev. Infect. Dis. 8 1986 S172 S181","journal-title":"Rev. Infect. Dis."},{"key":"e_1_3_2_23_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A3.\n          1993\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_24_2","unstructured":"National Institutes of Health. 1998. [Online.]http:\/\/www.ncbi.nlm.:nih.gov [2 March 1999 date last accessed.]"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/40.1.1","article-title":"Inhibitor-resistant \u03b2-lactamases.","volume":"40","author":"Nicolas M. H.","year":"1997","unstructured":"Nicolas M. H. Inhibitor-resistant \u03b2-lactamases. J. Antimicrob. Chemother. 40 1997 1 3","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.12.2096"},{"key":"e_1_3_2_27_2","first-page":"45","article-title":"Novel carbenicillin-hydrolyzing \u03b2-lactamase (CARB-5) from Acinetobacter calcoaticus var. anitratus.","volume":"59","author":"Paul G.","year":"1989","unstructured":"Paul G. Joly-Guillou M. L. Bergogne-Berezin E. N\u00e9vot P. Philippon A. Novel carbenicillin-hydrolyzing \u03b2-lactamase (CARB-5) from Acinetobacter calcoaticus var. anitratus. FEMS Microbiol. Lett. 59 1989 45 50","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.4.767"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2188"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01586193","article-title":"Changes in susceptibility of Salmonella enteriditidis,Salmonella typhimurium, and Salmonella virchow to six antimicrobial agents in a Spanish hospital, 1980\u20131994.","volume":"15","author":"Ramos J. M.","year":"1996","unstructured":"Ramos J. M. Ales J. M. Cuenca-Estrella M. Fernandez-Roblas R. Soriano F. Changes in susceptibility of Salmonella enteriditidis,Salmonella typhimurium, and Salmonella virchow to six antimicrobial agents in a Spanish hospital, 1980\u20131994. Eur. J. Clin. Microbiol. Infect. Dis. 15 1996 85 88","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-141-12-3015"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/jac\/27.5.569","article-title":"Factors determining resistance to \u03b2-lactam combined with \u03b2-lactamase inhibitors in Escherichia coli.","volume":"27","author":"Reguera J. A.","year":"1991","unstructured":"Reguera J. A. Baquero F. Perez-Diaz J. C. Martinez J. L. Factors determining resistance to \u03b2-lactam combined with \u03b2-lactamase inhibitors in Escherichia coli. J. Antimicrob. Chemother. 27 1991 569 573","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_33_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/mdr.1998.4.113","article-title":"Molecular epidemiology of antibiotic resistance genes in multiresistant epidemic Salmonella typhimurium DT104.","volume":"4","author":"Ridley A.","year":"1998","unstructured":"Ridley A. Threlfall E. J. Molecular epidemiology of antibiotic resistance genes in multiresistant epidemic Salmonella typhimurium DT104. Microb. Drug Resist. 4 1998 113 118","journal-title":"Microb. Drug Resist."},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/jac\/36.4.697","article-title":"Non-typhoid Salmonella spp. resistant to cefotaxime.","volume":"36","author":"Rossi A.","year":"1995","unstructured":"Rossi A. Lopardo H. Woloj M. Picandet A. M. Marino M. Galds M. Radice M. Gutkind G. Non-typhoid Salmonella spp. resistant to cefotaxime. J. Antimicrob. Chemother. 36 1995 697 702","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.1995.1.195"},{"key":"e_1_3_2_36_2","unstructured":"Sambrook\n              J. E.\n              Fritsch\n              F.\n              Maniatis\n              T.\n          Molecular cloning: a laboratory manual\n          2nd ed.\n          1989\n          Cold Spring Harbor Laboratory Press\n          Cold Spring Harbor N.Y"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.9.1365"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1997.tb12770.x"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.62.7.2375-2380.1996"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.1.67"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.8.3737"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.9.2233-2239.1995"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/plas.1993.1004","article-title":"Genetic organization of antibiotic resistance genes (aac(6\u2032)-Ib,aadA, and oxa-9) in the multiresistance transposon Tn1331.","volume":"29","author":"Tolmasky M. E.","year":"1993","unstructured":"Tolmasky M. E. Crosa J. H. Genetic organization of antibiotic resistance genes (aac(6\u2032)-Ib,aadA, and oxa-9) in the multiresistance transposon Tn1331. Plasmid 29 1993 31 40","journal-title":"Plasmid"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.12.3053"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.5.1322-1325.1994"},{"key":"e_1_3_2_46_2","first-page":"R130","article-title":"A case control study of infection with an epidemic strain of multiresistant Salmonella typhimurium DT104 in England and Wales.","volume":"4","author":"Wall P. G.","year":"1994","unstructured":"Wall P. G. Morgan D. Lamden K. Ryan M. Griffin M. Threlfall E. J. Ward L. R. Rowe B. A case control study of infection with an epidemic strain of multiresistant Salmonella typhimurium DT104 in England and Wales. Commun. Dis. Rep. CDR Rev. 4 1994 R130 R135","journal-title":"Commun. Dis. Rep. CDR Rev."},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.22.6531"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.9.1385"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.9.1915"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.5.1098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.5.1098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:21:19Z","timestamp":1645460479000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.5.1098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["10.1128\/AAC.43.5.1098"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.5.1098","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5]]},"assertion":[{"value":"1998-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}