{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:38:34Z","timestamp":1790775514402,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A clinical isolate of\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    RP-1 produced the extended-spectrum \u03b2-lactamase (ESBL) SHV-2a. Its gene was expressed from a composite promoter made of the \u221235 region derived from the left inverted repeat of IS\n                    <jats:italic>26<\/jats:italic>\n                    and the \u221210 region from the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>SHV-2a<\/jats:sub>\n                    promoter itself. The DNA sequences immediately surrounding\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>SHV-2a<\/jats:sub>\n                    were homologous to plasmid pMPA2a from\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    KpZU-3, while further away and 3\u2032 to the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>SHV-2a<\/jats:sub>\n                    gene, a sequence corresponding to the left end of Tn\n                    <jats:italic>1721<\/jats:italic>\n                    was detected, thus indicating a likely enterobacterial origin of this ESBL gene.\n                  <\/jats:p>","DOI":"10.1128\/aac.43.5.1281","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:34:57Z","timestamp":1539030897000},"page":"1281-1284","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":89,"title":["An SHV-Derived Extended-Spectrum \u03b2-Lactamase in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"43","author":[{"given":"Thierry","family":"Naas","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, Faculte\u0301 de Me\u0301decine Paris-Sud, 94275 Le Kremlin-Bice\u0302tre,1"},{"name":"<!--label omitted: 2-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital Antoine Be\u0301cle\u0300re, Faculte\u0301 de Me\u0301decine Paris-Sud, 92141 Clamart Cedex,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Philippon","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, Faculte\u0301 de Me\u0301decine Paris-Sud, 94275 Le Kremlin-Bice\u0302tre,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, Faculte\u0301 de Me\u0301decine Paris-Sud, 94275 Le Kremlin-Bice\u0302tre,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esthel","family":"Ronco","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Service de Microbiologie, Ho\u0302pital Raymond Poincare\u0301, Faculte\u0301de Me\u0301decine Paris-Ouest, 92380 Garches,3Assistance Publique\/Ho\u0302pitaux de Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, Faculte\u0301 de Me\u0301decine Paris-Sud, 94275 Le Kremlin-Bice\u0302tre,1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(92)90597-I"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1980.0049"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.6.1380"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-43-4-300"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/35.2.281"},{"key":"e_1_3_2_8_2","unstructured":"Galas\n              D. 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Microbiol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.8.2237"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.9.1697"},{"key":"e_1_3_2_12_2","first-page":"1446","article-title":"Survey of Klebsiella pneumoniae strains producing extended-spectrum \u03b2-lactamases: prevalence of SHV-12 and SHV-2a in Korea.","volume":"36","author":"Kim J.","year":"1998","unstructured":"Kim J. Kwon Y. Pai H. Kim J. W. Cho D. T. Survey of Klebsiella pneumoniae strains producing extended-spectrum \u03b2-lactamases: prevalence of SHV-12 and SHV-2a in Korea. Antimicrob. Agents Chemother. 36 1998 1446 1449","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.6.3229-3236.1990"},{"key":"e_1_3_2_14_2","unstructured":"Maslow\n              J. N.\n              Slutsky\n              A. M.\n              Arbeit\n              R. D.\n          Application of pulse-field gel electrophoresis to molecular microbiology\n          Diagnostic molecular microbiology: principles and applications.\n              Persing\n              D. H.\n              Smith\n              T. F.\n              Tenover\n              F. C.\n              White\n              T. J.\n          1993\n          563\n          572\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.12.3304"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.18.6319"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.11.2488"},{"key":"e_1_3_2_18_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 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