{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:58:29Z","timestamp":1784372309395,"version":"3.55.0"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The antibacterial activities of amoxicillin-gentamicin, trovafloxacin, trimethoprim-sulfamethoxazole (TMP-SMX) and the combination of trovafloxacin with TMP-SMX were compared in a model of meningoencephalitis due to\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            in infant rats. At 22 h after intracisternal infection, the cerebrospinal fluid was cultured to document meningitis, and the treatment was started. Treatment was instituted for 48 h, and efficacy was evaluated 24 h after administration of the last dose. All tested treatment regimens exhibited significant activities in brain, liver, and blood compared to infected rats receiving saline (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). In the brain, amoxicillin plus gentamicin was more active than all of the other regimens, and trovafloxacin was more active than TMP-SMX (bacterial titers of 4.1 \u00b1 0.5 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml for amoxicillin-gentamicin, 5.0 \u00b1 0.4 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml for trovafloxacin, and 5.8 \u00b1 0.5 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml for TMP-SMX;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). In liver, amoxicillin-gentamicin and trovafloxacin were similarly active (2.8 \u00b1 0.8 and 2.7 \u00b1 0.8 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml, respectively) but more active than TMP-SMX (4.4 \u00b1 0.6 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). The combination of trovafloxacin with TMP-SMX did not alter the antibacterial effect in the brain, but it did reduce the effect of trovafloxacin in the liver. Amoxicillin-gentamicin was the most active therapy in this study, but the activity of trovafloxacin suggests that further studies with this drug for the treatment of\n            <jats:italic>Listeria<\/jats:italic>\n            infections may be warranted.\n          <\/jats:p>","DOI":"10.1128\/aac.43.7.1651","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:35:16Z","timestamp":1539045316000},"page":"1651-1656","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Comparative Efficacies of Antibiotics in a Rat Model of Meningoencephalitis Due to\n            <i>Listeria monocytogenes<\/i>"],"prefix":"10.1128","volume":"43","author":[{"given":"Christian","family":"Michelet","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology, CH-3010 Bern, Switzerland,1 and"},{"name":"<!--label omitted: 2-->Clinique des Maladies Infectieuses2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology, CH-3010 Bern, Switzerland,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Bentue-Ferrer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Clinique de Pharmacologie Clinique,3 Ho\u0302pital Pontchaillou, 35033 Rennes Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Ta\u0308uber","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology, CH-3010 Bern, Switzerland,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.6.1298"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.11.4268-4276.1995"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/BF01700413","article-title":"In vitro extracellular and intracellular activity of two newer and two earlier fluoroquinolones against Listeria monocytogenes.","volume":"16","author":"Facinelli B.","year":"1997","unstructured":"Facinelli B. 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