{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:39:29Z","timestamp":1761129569415},"reference-count":17,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Sordarins are new antifungals which inhibit fungal protein synthesis by blocking elongation factor 2. Three compounds were evaluated in a murine model of histoplasmosis. Immune-competent mice were infected intravenously with 10\n            <jats:sup>6<\/jats:sup>\n            to 10\n            <jats:sup>8<\/jats:sup>\n            CFU of\n            <jats:italic>Histoplasma capsulatum<\/jats:italic>\n            yeast cells. Mice were treated either orally with sordarins or fluconazole from day 2 through 8 after infection or intraperitoneally with amphotericin B during the same period. Protection was measured by increased rates of survival for 30 days after infection or reduction of lung or kidney tissue counts 9 days after infection. All three of the antifungal drugs tested were protective compared with controls. Sordarins were effective at doses as low as 2 mg\/kg of body weight\/day. This novel class of drugs compared favorably with amphotericin B and fluconazole for the treatment of histoplasmosis.\n          <\/jats:p>","DOI":"10.1128\/aac.43.7.1716","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:35:16Z","timestamp":1539045316000},"page":"1716-1718","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Activities of Sordarins in Murine Histoplasmosis"],"prefix":"10.1128","volume":"43","author":[{"given":"John R.","family":"Graybill","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->University of Texas Health Science Center1 and"},{"name":"<!--label omitted: 2-->Veterans Administration Hospital,2 San Antonio, Texas, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Najvar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->University of Texas Health Science Center1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Fothergill","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Veterans Administration Hospital,2 San Antonio, Texas, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->University of Texas Health Science Center1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Gomez","family":"de las Heras","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Glaxo Wellcome SA, Tres Cantos, Madrid, Spain3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Aliouat\n              E. M.\n              Aviles\n              P.\n              Dei-Cas\n              E.\n              Herreros\n              E.\n              Dujardin\n              L.\n              Gargallo-Viola\n              D.\n          In vitro pharmaodynamic [sic] parameters of sordarin derivatives in comparison with marketed compounds against rat-derived Pneumocystis carinii abstr. J-15\n          Abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1998\n          454\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_3_2","unstructured":"Alvarez\n              M. E.\n              Herreros\n              E.\n              Sanchez-Sousa\n              A.\n              Gargallo-Viola\n              D.\n              Baquero\n              F.\n          In vitro activity of sordarins in combination with other systemic antifungal agents against Candida albicans Aspergillus spp. and Scedosporium apiospermun [sic] abstr. J-12\n          Abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1998\n          454\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_4_2","unstructured":"Aviles\n              P.\n              Falcoz\n              C.\n              Efthymiopoulos\n              C.\n              San Roman\n              R.\n              Martinez\n              A.\n              Jimenez\n              E.\n              Marriott\n              M. S.\n              Bye\n              A.\n              Gomez De Las Heras\n              F.\n              Gargallo-Viola\n              D.\n          Pharmacokinetic\/pharmacodynamic (PK\/PD) study of sordarin derivatives in a lethal C. albicans infection in mice abstr. J-74\n          Abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1998\n          472\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2694"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2274"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2279"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"25041","DOI":"10.1074\/jbc.273.39.25041","article-title":"Ribosomal P-protein stalk function is targeted by sodarin antifungals.","volume":"273","author":"Gomez M. 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J-83\n          Abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1998\n          474\n          American Society for Microbiology\n          Washington D.C"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.7.1716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.7.1716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:27:10Z","timestamp":1645460830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.7.1716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1128\/AAC.43.7.1716"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.7.1716","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]},"assertion":[{"value":"1998-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}