{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T10:13:50Z","timestamp":1649067230511},"reference-count":6,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro activity of HSR-903, an oral quinolone, against 196 recent clinical isolates of respiratory pathogens was evaluated. HSR-903 was 2 to 32 times more active than ofloxacin, ciprofloxacin, and sparfloxacin against\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            , including methicillin-resistant strains, and\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            and was at least as active as the other quinolones against gram-negative pathogens.\n          <\/jats:p>","DOI":"10.1128\/aac.43.7.1767","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:35:16Z","timestamp":1539045316000},"page":"1767-1768","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["In Vitro Activity of HSR-903, a New Oral Quinolone, against Bacteria Causing Respiratory Infections"],"prefix":"10.1128","volume":"43","author":[{"given":"Akira","family":"Watanabe","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Tokue","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Gomi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Fujimura","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nukiwa","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"183","article-title":"Methods for the determination of minimum inhibitory concentration (MIC) by microdilution method.","volume":"41","author":"Japan Society of Chemotherapy","year":"1993","unstructured":"Japan Society of Chemotherapy Methods for the determination of minimum inhibitory concentration (MIC) by microdilution method. Chemotherapy (Tokyo) 41 1993 183 189","journal-title":"Chemotherapy (Tokyo)"},{"key":"e_1_3_2_3_2","unstructured":"Okezaki\n              E.\n              Watanabe\n              Y.\n              Hirose\n              T.\n              Yoshida\n              T.\n              Aoki\n              Y.\n              Kato\n              H.\n          Antibacterial activity of HSR-903 a new novel quinolone abstr. F202\n          Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1995\n          148\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.6.1326"},{"key":"e_1_3_2_5_2","unstructured":"Umemura\n              K.\n              Mizuno\n              A.\n              Nakashima\n              M.\n          Pharmacokinetics and safety of HSR-903 in healthy volunteers abstr. F60\n          Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1996\n          110\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_6_2","unstructured":"Yoshida\n              T.\n              Kado\n              N.\n              Okezaki\n              E.\n              Yasuda\n              S.\n              Kato\n              H.\n          Synthesis and antibacterial activity of HSR-903 and related compounds abstr. F58\n          Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1996\n          110\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.4.785"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.7.1767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.7.1767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:17:58Z","timestamp":1645460278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.7.1767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1128\/AAC.43.7.1767"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.7.1767","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]},"assertion":[{"value":"1998-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}