{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:02:25Z","timestamp":1790420545266,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            ,\n            <jats:italic>Klebsiella oxytoca<\/jats:italic>\n            ,\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            , and\n            <jats:italic>Enterobacter aerogenes<\/jats:italic>\n            . Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against\n            <jats:italic>K. pneumoniae<\/jats:italic>\n            and\n            <jats:italic>E. aerogenes<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.43.8.2051","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:35:20Z","timestamp":1539045320000},"page":"2051-2055","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Comparative In Vitro Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against\n            <i>Klebsiella pneumoniae<\/i>\n            ,\n            <i>Klebsiella oxytoca<\/i>\n            ,\n            <i>Enterobacter cloacae<\/i>\n            , and\n            <i>Enterobacter aerogenes<\/i>\n            Clinical Isolates with Alterations in GyrA and ParC Proteins"],"prefix":"10.1128","volume":"43","author":[{"given":"Sylvain","family":"Brisse","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Eijkman-Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Milatovic","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Eijkman-Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad C.","family":"Fluit","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Eijkman-Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Verhoef","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Eijkman-Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Martin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute for Medical Microbiology and Virology, University Hospital Du\u0308sseldorf, D-40225 Du\u0308sseldorf, Germany2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybille","family":"Scheuring","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute for Medical Microbiology and Virology, University Hospital Du\u0308sseldorf, D-40225 Du\u0308sseldorf, Germany2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Ko\u0308hrer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Institute for Medical Microbiology and Virology, University Hospital Du\u0308sseldorf, D-40225 Du\u0308sseldorf, Germany2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz-Josef","family":"Schmitz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Eijkman-Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands,1and"},{"name":"<!--label omitted: 2-->Institute for Medical Microbiology and Virology, University Hospital Du\u0308sseldorf, D-40225 Du\u0308sseldorf, Germany2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jac\/32.4.605","article-title":"High-level quinolone resistance amongst clinical isolates of Escherichia coli and Klebsiella pneumoniae from Spain.","volume":"32","author":"Alarcon T.","year":"1993","unstructured":"Alarcon T. Pita J. Lopez-Brea M. Piddock L. J. High-level quinolone resistance amongst clinical isolates of Escherichia coli and Klebsiella pneumoniae from Spain. J. Antimicrob. Chemother. 32 1993 605 609","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.5.639"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/jac\/34.6.1074","article-title":"Multiclonal emergence of ciprofloxacin-resistant clinical isolates of Escherichia coli and Klebsiella pneumoniae.","volume":"34","author":"Bauernfeind A.","year":"1994","unstructured":"Bauernfeind A. Abele-Horn M. Emmerling P. Jungwirth R. Multiclonal emergence of ciprofloxacin-resistant clinical isolates of Escherichia coli and Klebsiella pneumoniae. J. Antimicrob. Chemother. 34 1994 1074 1076","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01297.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.2.561"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.1020"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.699"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.4.543"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/nar\/18.1.151","article-title":"Cloning and sequence analysis of gyrA gene of Klebsiella pneumoniae.","volume":"18","author":"Dimri G. P.","year":"1990","unstructured":"Dimri G. P. Das H. K. Cloning and sequence analysis of gyrA gene of Klebsiella pneumoniae. Nucleic Acid Res. 18 1990 151 156","journal-title":"Nucleic Acid Res."},{"key":"e_1_3_2_11_2","unstructured":"Gootz\n              T. D.\n              Brighty\n              K. E.\n          Chemistry and mechanism of action of the quinolone antibacterials\n          The quinolones.\n              Andriole\n              V. T.\n          1998\n          29\n          80\n          Academic Press\n          San Diego Calif"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.4.696"},{"key":"e_1_3_2_13_2","first-page":"49","article-title":"Bacterial resistance to fluoroquinolones: mechanisms and patterns.","volume":"390","author":"Hooper D. C.","year":"1995","unstructured":"Hooper D. C. Bacterial resistance to fluoroquinolones: mechanisms and patterns. Adv. Exp. Med. Biol. 390 1995 49 57","journal-title":"Adv. Exp. Med. Biol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0732-8893(94)90033-7","article-title":"Prevalence of important pathogens and antimicrobial activity of parenteral drugs at numerous medical centers in the United States.","volume":"19","author":"Jones R. N.","year":"1994","unstructured":"Jones R. N. Kehrberg E. N. Erwin M. E. Anderson S. C. the Fluoroquinolone Resistance Surveillance Group Prevalence of important pathogens and antimicrobial activity of parenteral drugs at numerous medical centers in the United States. Diagn. Microbiol. Infect. Dis. 19 1994 203 215","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90172-B"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11801"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.3.710"},{"key":"e_1_3_2_18_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial tests for bacteria that grow aerobically. Approved standard M7-A4.\n          1997\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.5.1249"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/42.4.489"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2661"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1271"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.8.2051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.43.8.2051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:21:21Z","timestamp":1645460481000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.43.8.2051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["10.1128\/AAC.43.8.2051"],"URL":"https:\/\/doi.org\/10.1128\/aac.43.8.2051","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]},"assertion":[{"value":"1999-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}