{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T16:08:43Z","timestamp":1715962123440},"reference-count":37,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We examined the in vivo activity of human macrophage colony-stimulating factor (hM-CSF) against lethal<jats:italic>Candida albicans<\/jats:italic>infection in mice. In<jats:italic>C. albicans<\/jats:italic>-infected mice which had been immunosuppressed with cyclophosphamide, treatment with hM-CSF at a daily dose of 8 \u00d7 10<jats:sup>5<\/jats:sup>units\/kg of body weight or greater slightly but significantly prolonged survival. Furthermore, the therapeutic efficacy of amphotericin B (AMPH-B) in infected mice was enhanced by its combined use with hM-CSF, while that of fluconazole (FLCZ) was not. The activities of peritoneal macrophages and neutrophils from mice administered hM-CSF plus AMPH-B in combination for inhibition of hyphal growth of<jats:italic>C. albicans<\/jats:italic>cells and intracellular phagocytosis and killing of the cells were greater than those of comparable phagocytic cells from control mice to which hM-CSF plus AMPH-B was not administered. These results suggest that intravenous administration of hM-CSF augments the efficacy of AMPH-B by enhancing the antifungal activities of macrophages and neutrophils. Therefore, it is expected that therapy with the combination AMPH-B and hM-CSF could improve the efficacy of AMPH-B and reduce the therapeutic dose of the antifungal drug that is required.<\/jats:p>","DOI":"10.1128\/aac.44.1.19-23.2000","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T05:03:57Z","timestamp":1240376637000},"page":"19-23","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Therapeutic Efficacy of Human Macrophage Colony-Stimulating Factor, Used Alone and in Combination with Antifungal Agents, in Mice with Systemic<i>Candida albicans<\/i>Infection"],"prefix":"10.1128","volume":"44","author":[{"given":"Tetsuya","family":"Kuhara","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Biochemical Research Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Uchida","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Research Center for Medical Mycology, Teikyo University, Tokyo,2 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Research Center for Medical Mycology, Teikyo University, Tokyo,2 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1348-0421.1994.tb01795.x","article-title":"A rapid colorimetric assay for determination of leukocyte-mediated inhibition of mycelial growth of Candida albicans.","volume":"38","author":"Abe S.","year":"1994","unstructured":"Abe S. 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