{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:14:49Z","timestamp":1785240889428,"version":"3.55.0"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We examined the antimicrobial susceptibilities of 85\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            isolates, classified according to the presence of amino acid substitutions in the GyrA and ParC proteins, to 12 fluoroquinolones and 7 other antibiotics. Sitafloxacin and HSR-903 showed excellent activity against\n            <jats:italic>N. gonorrhoeae<\/jats:italic>\n            , including strains with both GyrA and ParC substitutions. Among the strains with various GyrA substitutions, strains with a serine-91-to-phenylalanine mutation required the highest MICs of all of the fluoroquinolones tested and were cross-resistant to structurally unrelated \u03b2-lactams.\n          <\/jats:p>","DOI":"10.1128\/aac.44.1.192-195.2000","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T05:03:57Z","timestamp":1240376637000},"page":"192-195","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Susceptibilities of\n            <i>Neisseria gonorrhoeae<\/i>\n            Isolates Containing Amino Acid Substitutions in GyrA, with or without Substitutions in ParC, to Newer Fluoroquinolones and Other Antibiotics"],"prefix":"10.1128","volume":"44","author":[{"given":"Masatoshi","family":"Tanaka","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Urology, Faculty of Medicine, Kyushu University,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Nakayama Urologic Clinic,2 Fukuoka, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Haraoka","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Urology, Faculty of Medicine, Kyushu University,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Saika","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Chemotherapy Division, Mitsubishi-kagaku BCL, Tokyo,3 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Intetsu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Chemotherapy Division, Mitsubishi-kagaku BCL, Tokyo,3 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Naito","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Urology, Faculty of Medicine, Kyushu University,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01297.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.1020"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1086\/516472","article-title":"Antimicrobial resistance in Neisseria gonorrhoeae in the United States, 1988\u20131994: the emergence of decreased susceptibility to the fluoroquinolones.","volume":"175","author":"Fox K. K.","year":"1997","unstructured":"Fox K. K. Knapp J. S. Holmes K. K. Hook E. W. III Judson F. N. Thompson S. E. Washington J. A. Whittington W. L. Antimicrobial resistance in Neisseria gonorrhoeae in the United States, 1988\u20131994: the emergence of decreased susceptibility to the fluoroquinolones. J. Infect. Dis. 175 1997 1396 1403","journal-title":"J. Infect. Dis."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.11.2799"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.14.4162-4165.1995"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0140-6736(98)90003-4","article-title":"The epidemiology of global antibiotic resistance among Neisseria gonorrhoeae and Haemophilus ducreyi.","volume":"351","author":"Ison C. A.","year":"1998","unstructured":"Ison C. A. Dillon J. A. R. Tapsall J. W. The epidemiology of global antibiotic resistance among Neisseria gonorrhoeae and Haemophilus ducreyi. Lancet 351 (Suppl. III) 1998 8 11","journal-title":"Lancet"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.170"},{"key":"e_1_3_1_9_2","unstructured":"National Comittee for Clinical Laboratory Standards\n          Performance standards for antimicrobial susceptibility testing. Eighth informational supplement. Document M100-S8\n          18 no. 1\n          1998\n          National Comittee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.579"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199810000-00009"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199509000-00007"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.1.192-195.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.1.192-195.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:31:52Z","timestamp":1645461112000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.44.1.192-195.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1128\/AAC.44.1.192-195.2000"],"URL":"https:\/\/doi.org\/10.1128\/aac.44.1.192-195.2000","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"1999-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}