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In this study, treatment with a polyamine analogue (SL-11047) prevented<jats:italic>C. parvum<\/jats:italic>infection in suckling TCR-\u03b1-deficient mice and cleared an existing infection in older mice. Treatment with putrescine, while capable of preventing infection, did not clear<jats:italic>C. parvum<\/jats:italic>from previously infected mice. These findings provide further evidence that polyamine metabolic pathways are targets for new anticryptosporidial chemotherapeutic agents.<\/jats:p>","DOI":"10.1128\/aac.44.10.2891-2894.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"2891-2894","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["[<sup>1<\/sup>N,<sup>12<\/sup>N]Bis(Ethyl)-<i>cis<\/i>-6,7-Dehydrospermine: a New Drug for Treatment and Prevention of<i>Cryptosporidium parvum<\/i>Infection of Mice Deficient in T-Cell Receptor Alpha"],"prefix":"10.1128","volume":"44","author":[{"given":"W. 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