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In acute disseminated<jats:italic>Candida albicans<\/jats:italic>and<jats:italic>Aspergillus fumigatus<\/jats:italic>infections, treatment at 5 mg\/kg of body weight twice a day (b.i.d.) significantly prolonged survival. In these models and in animals with chronic disseminated cryptococcosis, itraconazole given i.v. at 2.5 and 5 mg\/kg b.i.d. greatly reduced the proportions of organs with culture-detectable fungal burdens. The efficacy of i.v. itraconazole in these animal models justifies its further investigation for the treatment of life-threatening mycoses in humans.<\/jats:p>","DOI":"10.1128\/aac.44.11.3180-3183.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"3180-3183","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Activities of an Intravenous Formulation of Itraconazole in Experimental Disseminated<i>Aspergillus<\/i>,<i>Candida<\/i>, and<i>Cryptococcus<\/i>Infections"],"prefix":"10.1128","volume":"44","author":[{"given":"Frank C.","family":"Odds","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, Scotland, United Kingdom,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Oris","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Bacteriology and Mycology, Janssen Research Foundation, B-2340 Beerse, Belgium2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Van Dorsselaer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Bacteriology and Mycology, Janssen Research Foundation, B-2340 Beerse, Belgium2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans","family":"Van Gerven","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Bacteriology and Mycology, Janssen Research Foundation, B-2340 Beerse, Belgium2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1077"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.4.615"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90023-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/514504"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401137"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","unstructured":"Graybill J. 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