{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:36:22Z","timestamp":1789846582264,"version":"4.0.1"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A relationship between resistance to methicillin and resistance to fluoroquinolones, rifampin, and mupirocin has been described for\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            . Differences in resistance rates may be explainable by a higher spontaneous mutation rate (MR) or a faster development of resistance (DIFF) in methicillin-resistant\n            <jats:italic>S. aureus<\/jats:italic>\n            (MRSA). No differences in MR, DIFF, and mutations in\n            <jats:italic>grlA<\/jats:italic>\n            and\n            <jats:italic>gyrA<\/jats:italic>\n            were detected between methicillin-susceptible\n            <jats:italic>S. aureus<\/jats:italic>\n            and MRSA. The higher resistance rates in MRSA are not the result of hypermutability of target genes or a faster emergence of different mutations and may be the consequence of clonal spread of multiresistant MRSA.\n          <\/jats:p>","DOI":"10.1128\/aac.44.11.3229-3231.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"3229-3231","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Development of Resistance to Ciprofloxacin, Rifampin, and Mupirocin in Methicillin-Susceptible and -Resistant\n            <i>Staphylococcus aureus<\/i>\n            Isolates"],"prefix":"10.1128","volume":"44","author":[{"given":"Franz-Josef","family":"Schmitz","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology and Virology1 and"},{"name":"<!--label omitted: 2-->Eijkman-Winkler Institute for Medical Microbiology, University Medical Center, Utrecht, The Netherlands2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad C.","family":"Fluit","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Eijkman-Winkler Institute for Medical Microbiology, University Medical Center, Utrecht, The Netherlands2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Hafner","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Institute for Pharmacology and Clinical Pharmacology,3 Heinrich-Heine Universita\u0308t Du\u0308sseldorf, Du\u0308sseldorf, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Beeck","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology and Virology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Perdikouli","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology and Virology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mechthild","family":"Boos","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology and Virology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybille","family":"Scheuring","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology and Virology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Verhoef","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Eijkman-Winkler Institute for Medical Microbiology, University Medical Center, Utrecht, The Netherlands2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Ko\u0308hrer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institute for Medical Microbiology and Virology1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Von Eiff","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Institute of Medical Microbiology, Westfa\u0308lische Wilhelms-Universita\u0308t, Mu\u0308nster,4Germany, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2590"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.154.1.479-487.1983"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.1.11"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.7.1554"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1054\/drup.1998.0068"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1208"},{"key":"e_1_3_1_8_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial tests for bacteria that grow aerobically. Approved standard M7-A4.\n          1997\n          National Committee for Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5469.1251"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/42.4.489"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-47-4-341"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.4.481"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1999.tb00158.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01400.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2813"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.11.3229-3231.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.11.3229-3231.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:38:20Z","timestamp":1645461500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.44.11.3229-3231.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2000,11]]}},"alternative-id":["10.1128\/AAC.44.11.3229-3231.2000"],"URL":"https:\/\/doi.org\/10.1128\/aac.44.11.3229-3231.2000","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11]]},"assertion":[{"value":"2000-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}