{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T08:11:57Z","timestamp":1769933517734,"version":"3.49.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            After oral administration of 500 mg of levofloxacin to 12 volunteers, we investigated the pharmacokinetics and serum bactericidal activities (SBAs) against five strains of members of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            . Pharmacokinetic data were as follows: maximum concentration in serum, 6.36 \u00b1 0.57 mg\/liter; area under the concentration-time curve, 43.6 \u00b1 6.23 mg \u00b7 h\/liter; elimination half-life 4.23 \u00b1 0.87 h. SBAs were present for 24 h against\n            <jats:italic>Escherichia coli<\/jats:italic>\n            and\n            <jats:italic>Citrobacter freundii<\/jats:italic>\n            . The SBAs at 1, 12, and 24 h after administration against\n            <jats:italic>E. coli<\/jats:italic>\n            were 1:108, 1:29, and 1:7, respectively, and those against\n            <jats:italic>Citrobacter freundii<\/jats:italic>\n            were 1:74, 1:25, and 1:7, respectively. The SBAs were present for 12 h against the other three organisms tested. The SBAs against\n            <jats:italic>Serratia marcescens<\/jats:italic>\n            were 1:28 and 1:9 at 1 and 12 h, respectively; the SBAs against\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            were 1:25 and 1:7 at 1 and 12 h, respectively; and the SBAs against\n            <jats:italic>Enterobacter cloacae<\/jats:italic>\n            were 1:24 and 1:10 at 1 and 12 h, respectively.\n          <\/jats:p>","DOI":"10.1128\/aac.44.12.3478-3480.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"3478-3480","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Levofloxacin Pharmacokinetics and Serum Bactericidal Activities against Five Enterobacterial Species"],"prefix":"10.1128","volume":"44","author":[{"given":"Hilte F.","family":"Geerdes-Fenge","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Pulmonary and Infectious Diseases1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Wiedersich","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pulmonary and Infectious Diseases1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wagner","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Clinical Microbiology,2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Lehr","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->City Hospital Zehlendorf\/Heckeshorn, Freie Universit\u00e4t Berlin, 14109 Berlin, Department of Drug Metabolism &amp; Pharmacokinetics, Hoechst-Marion-Roussel, 65926 Frankfurt am Main,3and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Koeppe","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Department of Medical Physics and Laser Medicine, Klinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, 12200 Berlin,4 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Lode","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pulmonary and Infectious Diseases1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.5.639"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.7.1562"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2256"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/516284"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199447040-00008"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.3.483"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199732020-00002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.4.860"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000238777"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/129.2.187"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2196"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(88)80015-X"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/514623"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17178"},{"key":"e_1_3_2_16_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methodology for the serum bactericidal test; tentative guideline. NCCLS document M21-T.\n          1992\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_17_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically\n          3rd ed. Approved standard M7\u2013A3\n          1993\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1998.tb00054.x"},{"key":"e_1_3_2_19_2","unstructured":"Ott\n              L.\n          An introduction to statistical methods and data analysis\n          3rd ed.\n          1988\n          323\n          324\n          PWS-Kent Publishing Company\n          Boston Mass"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.3.701"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.6.3.330"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.2.125"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344136"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90662-4"},{"key":"e_1_3_2_25_2","unstructured":"Shargel\n              L.\n              Yu\n              A. B. C.\n          Applied biopharmaceutics and pharmacokinetics\n          3rd ed.\n          1993\n          Appleton and Lange\n          Norwalk Conn"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504113121507"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.12.3478-3480.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.12.3478-3480.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:23:45Z","timestamp":1645460625000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.44.12.3478-3480.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1128\/AAC.44.12.3478-3480.2000"],"URL":"https:\/\/doi.org\/10.1128\/aac.44.12.3478-3480.2000","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]},"assertion":[{"value":"1999-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}