{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:48:39Z","timestamp":1761511719225},"reference-count":33,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            From January 1991 to June 1997, patients undergoing primary elective monolateral or bilateral total knee replacement (TKR) were consecutively enrolled in a prospective, open clinical study on the efficacy and safety of regional prophylaxis with teicoplanin (TEC). Those scheduled for monolateral TKR (115 patients) received 400 mg of TEC in 100 ml of saline as a 5-min infusion into a foot vein of the leg to be operated on immediately after the tourniquet was inflated to 400 mm Hg (ca. 50 kPa). For patients undergoing bilateral surgery (45 patients), regional administration of TEC was also repeated for the second knee operation. Follow-up ranged from a minimum of 2 years to 8 years. None of the patients experienced local or systemic adverse effects following regional administration of TEC. In the immediate postoperative and 2-year follow-up periods, only one superficial infection of the primary site attributable to intraoperative contamination (prophylaxis failure) out of the 205 prostheses implanted was observed. Deep infections involving the prosthesis did not occur. Infectious complications at distant sites were observed in nine cases (urinary tract infection due to\n            <jats:italic>Escherichia coli<\/jats:italic>\n            in eight cases, and\n            <jats:italic>Salmonella enteritidis<\/jats:italic>\n            gastroenteritis in one case) in the immediate postoperative period; they all were rapidly cured after antibiotic treatment. A delayed prosthetic infection, related to hematogenous spread of the etiological agent and therefore not considered a prophylactic failure, was observed in a patient who had undergone TKR 5 years before. Regional administration of TEC in monolateral and bilateral TKR appears to be a safe and valuable prophylactic technique.\n          <\/jats:p>","DOI":"10.1128\/aac.44.2.316-319.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"316-319","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Regional Prophylaxis with Teicoplanin in Monolateral or Bilateral Total Knee Replacement: an Open Study"],"prefix":"10.1128","volume":"44","author":[{"given":"Fausto","family":"de Lalla","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases, San Bortolo Hospital,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Viola","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Center for Knee Surgery, Sandrigo Hospital,2 Vicenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampietro","family":"Pellizzer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases, San Bortolo Hospital,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Lazzarini","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases, San Bortolo Hospital,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tramarin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases, San Bortolo Hospital,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Fabris","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases, San Bortolo Hospital,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.2106\/00004623-197355060-00012","article-title":"A double blind clinical trial of prophylactic antibiotics in hip fracture.","volume":"55","author":"Boyd R. J.","year":"1973","unstructured":"Boyd R. J. Burke J. F. Colton T. A double blind clinical trial of prophylactic antibiotics in hip fracture. J. Bone Joint Surg. 55 1973 1251 1258","journal-title":"J. Bone Joint Surg."},{"key":"e_1_3_1_3_2","unstructured":"Brause\n              B. D.\n          Infected orthopedic prostheses\n          Infections associated with indwelling medical devices.\n              Bisno\n              A. L.\n              Waldvogel\n              F. A.\n          1989\n          111\n          127\n          American Society for Microbiology\n          Washington D.C."},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00003086-198803000-00018","article-title":"Cefazolin versus cefamandole for prophylaxis during total joint arthroplasty.","volume":"228","author":"Bryan C. S.","year":"1988","unstructured":"Bryan C. S. Morgan S. L. Caton R. J. Lunceford E. M. 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A review of the literature. Clin. Orthop. 296 1993 249 255","journal-title":"Clin. Orthop."},{"key":"e_1_3_1_26_2","first-page":"222","article-title":"Management of infection in total knee replacement.","volume":"9","author":"Paya C. V.","year":"1988","unstructured":"Paya C. V. Wilson W. R. Fitzgerald R. H. Jr. Management of infection in total knee replacement. Curr. Clin. Top. Infect. Dis. 9 1988 222 240","journal-title":"Curr. Clin. Top. Infect. Dis."},{"key":"e_1_3_1_27_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/jac\/41.3.329","article-title":"Antimicrobial prophylaxis in orthopaedic surgery: the role of teicoplanin.","volume":"41","author":"Periti P.","year":"1998","unstructured":"Periti P. Mini E. Mosconi G. Antimicrobial prophylaxis in orthopaedic surgery: the role of teicoplanin. J. Antimicrob. Chemother. 41 1998 329 340","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_1_28_2","unstructured":"Saravolatz\n              L. D.\n          Infections in implantable prosthetic devices\n          Prevention and control of nosocomial infections.\n              Wenzel\n              R. P.\n          1987\n          683\n          707\n          Williams & Wilkins\n          Baltimore Md"},{"key":"e_1_3_1_29_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/BF02111338","article-title":"Teicoplanin versus cefamandole in the prevention of total hip replacement.","volume":"13","author":"Suter F.","year":"1994","unstructured":"Suter F. Avai A. Fusco U. Gerundini M. Capriolo S. Maggiolo F. Teicoplanin versus cefamandole in the prevention of total hip replacement. Eur. J. Clin. Microbiol. Infect. Dis. 13 1994 793 796","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_1_30_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0195-6701(90)90112-2","article-title":"Perioperative wound infection in elective orthopaedic surgery.","volume":"16","author":"Taylor G. J. 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Chemother."},{"key":"e_1_3_1_32_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/jac\/21.2.201","article-title":"Antibiotic prophylaxis in cardiac surgery: serum and tissue levels of teicoplanin, flucloxacillin and tobramycin.","volume":"21","author":"Wilson A. P. R.","year":"1988","unstructured":"Wilson A. P. R. Taylor B. Treasure T. Grunenberg R. N. Patton K. Felmingham D. Sturridge M. F. Antibiotic prophylaxis in cardiac surgery: serum and tissue levels of teicoplanin, flucloxacillin and tobramycin. J. Antimicrob. Chemother. 21 1988 201 212","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_1_33_2","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0039-6109(16)40803-0","article-title":"The problem of infection in total prosthetic arthroplasty of the hip.","volume":"55","author":"Wilson P. D.","year":"1975","unstructured":"Wilson P. D. Jr. Salvati E. A. Blumenfeld E. L. The problem of infection in total prosthetic arthroplasty of the hip. Surg. Clin. N. Am. 55 1975 1431 1445","journal-title":"Surg. Clin. N. Am."},{"key":"e_1_3_1_34_2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/00001432-199010000-00016","article-title":"Prevention of infection in prosthetic joints.","volume":"3","author":"Young E. J.","year":"1990","unstructured":"Young E. J. Prevention of infection in prosthetic joints. Curr. Opin. Infect. Dis. 3 1990 666 669","journal-title":"Curr. Opin. Infect. 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