{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:04:05Z","timestamp":1771661045937,"version":"3.50.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The precise duration of therapy of multidrug-resistant (MDR) typhoid with broad-spectrum cephalosporins is uncertain. We prospectively randomized 57 children with culture-proven MDR typhoid to receive treatment with intravenous ceftriaxone (CRO) (65 mg\/kg of body weight\/day) for 7 days (short course;\n            <jats:italic>n<\/jats:italic>\n            = 29) or 14 days (conventional;\n            <jats:italic>n<\/jats:italic>\n            = 28). The response to therapy, as evaluated by the serial monitoring of the typhoid morbidity score and bacteriological clearance, was comparable between groups. In contrast to the conventional therapy, 14% of the children receiving CRO for 7 days had a confirmed bacteriological relapse within 4 weeks of stopping therapy.\n          <\/jats:p>","DOI":"10.1128\/aac.44.2.450-452.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"450-452","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Failure of Short-Course Ceftriaxone Chemotherapy for Multidrug-Resistant Typhoid Fever in Children: a Randomized Controlled Trial in Pakistan"],"prefix":"10.1128","volume":"44","author":[{"given":"Zulfiqar A.","family":"Bhutta","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Paediatrics, The Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iqtidar A.","family":"Khan","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Paediatrics, The Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoon","family":"Shadmani","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Paediatrics, The Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4269\/ajtmh.1995.52.162","article-title":"Treatment of typhoid fever: randomized trial of a three-day course of ceftriaxone versus a fourteen-day course of chloramphenicol.","volume":"52","author":"Acharya G.","year":"1995","unstructured":"Acharya G. Butler T. Ho M. Sharma P. R. Tiwari M. Adhikari R. K. Khagda J. B. Pokhrel B. Pathak U. N. Treatment of typhoid fever: randomized trial of a three-day course of ceftriaxone versus a fourteen-day course of chloramphenicol. Am. J. Trop. Med. Hyg. 52 1995 162 165","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4_ts.493"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/00006454-199411000-00010","article-title":"Therapy of multidrug-resistant typhoid fever with oral cefixime vs intravenous ceftriaxone.","volume":"13","author":"Bhutta Z. A.","year":"1994","unstructured":"Bhutta Z. A. Khan I. A. Molla A. M. Therapy of multidrug-resistant typhoid fever with oral cefixime vs intravenous ceftriaxone. Pediatr. Infect. Dis. J. 13 1994 990 994","journal-title":"Pediatr. Infect. Dis. 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