{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:33:48Z","timestamp":1762864428879},"reference-count":22,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In a rabbit model of\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            meningitis, 5 mg of gemifloxacin mesylate (SB-265805) per kg\/h reduced the bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as 10 mg of ceftriaxone per kg\/h (\u0394log CFU\/ml\/h \u00b1 standard deviation [SD], \u22120.25 \u00b1 0.09 versus \u22120.38 \u00b1 0.11; serum and CSF concentrations of gemifloxacin were 2.1 \u00b1 1.4 mg\/liter and 0.59 \u00b1 0.38 mg\/liter, respectively, at 24 h). Coadministration of 1 mg of dexamethasone per kg did not affect gemifloxacin serum and CSF levels (2.7 \u00b1 1.4 mg\/liter and 0.75 \u00b1 0.34 mg\/liter, respectively, at 24 h) or activity (\u0394log CFU\/ml\/h \u00b1 SD, \u22120.26 \u00b1 0.11).\n          <\/jats:p>","DOI":"10.1128\/aac.44.3.767-770.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"767-770","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Gemifloxacin Is Effective in Experimental Pneumococcal Meningitis"],"prefix":"10.1128","volume":"44","author":[{"given":"A.","family":"Smirnov","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Neurology, University of Go\u0308ttingen, Go\u0308ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wellmer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Neurology, University of Go\u0308ttingen, Go\u0308ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gerber","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Neurology, University of Go\u0308ttingen, Go\u0308ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Maier","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Neurology, University of Go\u0308ttingen, Go\u0308ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Henne","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Neurology, University of Go\u0308ttingen, Go\u0308ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Nau","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Neurology, University of Go\u0308ttingen, Go\u0308ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/00006454-199111000-00018","article-title":"Ceftriaxone failure in meningitis caused by Streptococcus pneumoniae with reduced susceptibility to beta-lactam antibiotics.","volume":"10","author":"Bradley J. 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