{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:53:27Z","timestamp":1790402007694,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The pharmacokinetic properties of oral and intravenous artesunate (2 mg\/kg of body weight) were studied in 19 adult patients with acute uncomplicated\n            <jats:italic>Plasmodium falciparum<\/jats:italic>\n            malaria by using a randomized crossover design. A sensitive bioassay was used to measure the antimalarial activity in plasma which results from artesunate and its principal metabolite, dihydroartemisinin. The oral study was repeated with 15 patients during convalescence. The mean absolute oral bioavailability of the antimalarial agent in patients with acute malaria was 61% (95% confidence interval [CI], 52 to 70%). The absorption and elimination of oral artesunate were rapid, with a mean elimination half-life of antimalarial activity of 43 min (95% CI, 33 to 53 min). Following oral administration to patients with acute falciparum malaria, peak antimalarial activity in plasma and the area under the plasma concentration-time curve were approximately double those during convalescence and the apparent volume of distribution and clearance were approximately half those during convalescence (\n            <jats:italic>P<\/jats:italic>\n            \u2264 0.005). Acute malaria is associated with a significant reduction in the clearance of artesunate-associated antimalarial activity.\n          <\/jats:p>","DOI":"10.1128\/aac.44.4.972-977.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"972-977","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":130,"title":["Antimalarial Bioavailability and Disposition of Artesunate in Acute Falciparum Malaria"],"prefix":"10.1128","volume":"44","author":[{"given":"Paul","family":"Newton","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Faculty of Tropical Medicine, Mahidol University,1"},{"name":"<!--label omitted: 2-->Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford,2and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupin","family":"Suputtamongkol","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Medicine, Siriraj Hospital,3 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paktiya","family":"Teja-Isavadharm","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences,4 Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasithon","family":"Pukrittayakamee","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Faculty of Tropical Medicine, Mahidol University,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Navaratnam","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->National Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Bates","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Liverpool School of Tropical Medicine, Liverpool,6 United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"White","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Faculty of Tropical Medicine, Mahidol University,1"},{"name":"<!--label omitted: 2-->Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford,2and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"25","article-title":"Artemisinin pharmacokinetics is time-dependent during repeated oral administration in healthy male adults.","volume":"26","author":"Ashton M.","year":"1998","unstructured":"Ashton M. 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