{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:37:29Z","timestamp":1761057449062},"reference-count":15,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro activity of telithromycin (HMR3647), a new ketolide, against\n            <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n            was determined by the broth microdilution test using 41 clinical isolates obtained in Japan, as compared with those of five macrolides (erythromycin, clarithromycin, roxithromycin, azithromycin, and josamycin), minocycline, and levofloxacin. Telithromycin was less potent than azithromycin, but it was more active than four other macrolides, minocycline, and levofloxacin; its MICs at which 50 and 90% of the isolates tested were inhibited were both 0.00097 \u03bcg\/ml, justifying clinical studies to determine its efficacy for treatment of\n            <jats:italic>M. pneumoniae<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.44.5.1381-1382.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1381-1382","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["In Vitro Activity of Telithromycin (HMR3647), a New Ketolide, against Clinical Isolates of\n            <i>Mycoplasma pneumoniae<\/i>\n            in Japan"],"prefix":"10.1128","volume":"44","author":[{"given":"Toshiyuki","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Laboratory Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Hirakata","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Laboratory Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Izumikawa","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Laboratory Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Laboratory Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigefumi","family":"Maesaki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->the Second Department of Internal Medicine,2 Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Tomono","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->the Second Department of Internal Medicine,2 Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Laboratory Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimeru","family":"Kamihira","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Laboratory Medicine1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->the Second Department of Internal Medicine,2 Nagasaki University School of Medicine, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.4.945"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.8.2138"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1073\/pnas.48.1.41","article-title":"Growth on artificial medium of an agent associated with atypical pneumonia and its identification as PPLO.","volume":"48","author":"Chanock R. 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