{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:29:00Z","timestamp":1776511740364,"version":"3.51.2"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activities of seven antimicrobial agents used for treatment and prophylaxis of meningococcal disease was investigated against 901\n            <jats:italic>Neisseria meningitidis<\/jats:italic>\n            isolates, 112 of which were recovered from patients and 789 of which were recovered from asymptomatic carriers. The proportions of isolates with decreased susceptibility to penicillin were 55.3 and 39.0%, respectively. Penicillin- and ampicillin-intermediate strains were more common among serogroup C meningococci than among non-serogroup C meningococci from both patients and carriers.\n          <\/jats:p>","DOI":"10.1128\/aac.44.6.1705-1707.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1705-1707","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Antibiotic Susceptibility Patterns of\n            <i>Neisseria meningitidis<\/i>\n            Isolates from Patients and Asymptomatic Carriers"],"prefix":"10.1128","volume":"44","author":[{"given":"L.","family":"Arreaza","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratorio de Referencia de Meningococos. Centro Nacional de Microbiolog\u0131\u0301a, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratorio de Referencia de Meningococos. Centro Nacional de Microbiolog\u0131\u0301a, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Va\u0301zquez","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratorio de Referencia de Meningococos. Centro Nacional de Microbiolog\u0131\u0301a, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF01739006","article-title":"First recorded outbreaks of meningococcal disease in the Israel defence force: three clusters due to serogroup C and the emergence of resistance to rifampicin.","volume":"22","author":"Almog R.","year":"1994","unstructured":"Almog R. Block C. Gdalevich M. Lev B. Wiener M. Ashkenazi S. First recorded outbreaks of meningococcal disease in the Israel defence force: three clusters due to serogroup C and the emergence of resistance to rifampicin. Infection 22 1994 69 71","journal-title":"Infection"},{"key":"e_1_3_2_3_2","first-page":"303","article-title":"MENSURA breakpoints. Spanish criteria for determination of susceptibility to antibiotics.","volume":"10","author":"Baquero F.","year":"1997","unstructured":"Baquero F. Mart\u0131\u0301nez-Beltr\u00e1n J. Cant\u00f3n R. MENSURA breakpoints. Spanish criteria for determination of susceptibility to antibiotics. Rev. Esp. Quimioter. 10 1997 303 313","journal-title":"Rev. Esp. Quimioter."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0140-6736(88)91029-X","article-title":"Penicillin resistant Neisseria meningitidis in Southern Africa.","author":"Botha P.","year":"1988","unstructured":"Botha P. Penicillin resistant Neisseria meningitidis in Southern Africa. Lancet i 1988 54","journal-title":"Lancet"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199111000-00018"},{"key":"e_1_3_2_6_2","unstructured":"Dean\n              A.\n              Dean\n              J.\n              Coulombier\n              D.\n              Brendel\n              K.\n              Smith\n              D.\n              Burton\n              A.\n              Dicker\n              R.\n              Sullivan\n              K.\n              Fagan\n              R.\n              Arner\n              T.\n          Epi-Info version 6.04: a word processing database and statistics program for epidemiology on microcomputers.\n          1994\n          Centers for Disease Control and Prevention\n          Atlanta Ga"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0140-6736(83)91846-9","article-title":"Spread of penicillin producing and transfer plasmids from gonococcus to Neisseria meningitidis.","author":"Dillon J. R.","year":"1983","unstructured":"Dillon J. R. Pauze M. Yeung K. H. Spread of penicillin producing and transfer plasmids from gonococcus to Neisseria meningitidis. Lancet i 1983 779 781","journal-title":"Lancet"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF01964130","article-title":"Penicillin-resistant beta-lactamase producing Neisseria meningitidis in Spain.","volume":"8","author":"Fontanals D.","year":"1989","unstructured":"Fontanals D. Pineda V. Pons I. Rojo J. C. Penicillin-resistant beta-lactamase producing Neisseria meningitidis in Spain. Eur. J. Clin. Microbiol. Infect. Dis. 8 1989 90 91","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90177-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.11.2277"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1086\/514917","article-title":"Horizontal genetic exchange, evolution and spread of antibiotic resistance in bacteria.","volume":"27","author":"Maiden M. C. J.","year":"1998","unstructured":"Maiden M. C. J. Horizontal genetic exchange, evolution and spread of antibiotic resistance in bacteria. Clin. Infect. Dis. 27 (Suppl. 1) 1998 S12 S20","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.5.706"},{"key":"e_1_3_2_13_2","unstructured":"Nadel\n              S.\n              Levin\n              M.\n              Habibi\n              P.\n          Treatment of meningococcal disease in childhood\n          Meningococcal disease.\n              Cartwright\n              K.\n          1995\n          207\n          243\n          John Wiley & Sons Ltd.\n          Chichester England"},{"key":"e_1_3_2_14_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Performance standards for antimicrobial susceptibility testing; ninth informational supplement. Document M100-S9.\n          1999\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.15.1.78-81.1982"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/clinids\/14.2.394","article-title":"Epidemiology and molecular basis of penicillin-resistant Neisseria meningitidis in Spain: a 5-year history (1985\u20131990).","volume":"14","author":"S\u00e1ez-Nieto J. A.","year":"1992","unstructured":"S\u00e1ez-Nieto J. A. Lujan R. Berr\u00f3n S. Campos J. Vi\u00f1as M. Fust\u00e9 C V\u00e1zquez J. A. Zhang Q-Y. Bowler L. D. Mart\u0131\u0301nez-Suarez J. V. Spratt B. G. Epidemiology and molecular basis of penicillin-resistant Neisseria meningitidis in Spain: a 5-year history (1985\u20131990). Clin. Infect. Dis. 14 1992 394 402","journal-title":"Clin. Infect. 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Penicillin-insensitive meningococci in the U.K. Lancet i 1988 657 658","journal-title":"Lancet"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199509000-00007"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01591498","article-title":"Isolation of a strain of beta-lactamase-producing Neisseria meningitidis in Spain.","volume":"15","author":"V\u00e1zquez J. A.","year":"1996","unstructured":"V\u00e1zquez J. A. Enriquez A. M. De la Fuente L. Berr\u00f3n S. Baquero M. Isolation of a strain of beta-lactamase-producing Neisseria meningitidis in Spain. Eur. J. Clin. Microbiol. Clin. 15 1996 181 182","journal-title":"Eur. J. Clin. Microbiol. Clin."},{"key":"e_1_3_2_21_2","first-page":"273","article-title":"Decrease in the incidence of moderately penicillin resistant meningococci (CMI\u22650.12micrograms\/ml).","volume":"14","author":"V\u00e1zquez J. A.","year":"1996","unstructured":"V\u00e1zquez J. A. Marcos C. De la Fuente L. Berr\u00f3n S. Decrease in the incidence of moderately penicillin resistant meningococci (CMI\u22650.12micrograms\/ml). Enf. Infec. Microbiol. Clin. 14 1996 273","journal-title":"Enf. Infec. Microbiol. 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