{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:56:58Z","timestamp":1789361818288,"version":"build-2803163510"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The transformation of a panel of\n            <jats:italic>rpoB<\/jats:italic>\n            mutations (codons 525 to 586) from rifampin-resistant donor strains into\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            2802A confirmed the MICs associated with the respective mutations.\n            <jats:italic>RpoB<\/jats:italic>\n            V149X random mutations were generated and induced different levels of resistance, depending on the replacement amino acid. Mutagenesis of the\n            <jats:italic>rpoB<\/jats:italic>\n            gene at codon position 701 (R701H) induced low-level resistance.\n          <\/jats:p>","DOI":"10.1128\/aac.44.6.1713-1715.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1713-1715","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Mutations at Four Distinct Regions of the\n            <i>rpoB<\/i>\n            Gene Can Reduce the Susceptibility of\n            <i>Helicobacter pylori<\/i>\n            to Rifamycins"],"prefix":"10.1128","volume":"44","author":[{"given":"Markus","family":"Heep","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Medizinische Mikrobiologie, Universita\u0308t Regensburg, Regensburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Odenbreit","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Max-von-Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Universita\u0308t Mu\u0308nchen, Munich,2 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Beck","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Medizinische Mikrobiologie, Universita\u0308t Regensburg, Regensburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Decker","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Medizinische Mikrobiologie, Universita\u0308t Regensburg, Regensburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Prohaska","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Medizinische Mikrobiologie, Universita\u0308t Regensburg, Regensburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Rieger","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Medizinische Mikrobiologie, Universita\u0308t Regensburg, Regensburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Lehn","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Institut fu\u0308r Medizinische Mikrobiologie, Universita\u0308t Regensburg, Regensburg,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.5.1072"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.6.1497"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.4.1075-1077.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(88)90517-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1093\/clinids\/22.Supplement_1.S3","article-title":"Antimicrobial activity of rifabutin.","volume":"22","author":"Kunin C. 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