{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:33:52Z","timestamp":1782952432562,"version":"3.54.5"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA) against\n            <jats:italic>Leishmania donovani<\/jats:italic>\n            parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes\/animal could significantly reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral leishmaniasis, respectively, suggesting their strong therapeutic potential.\n          <\/jats:p>","DOI":"10.1128\/aac.44.6.1739-1742.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1739-1742","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Antileishmanial Activities of Stearylamine-Bearing Liposomes"],"prefix":"10.1128","volume":"44","author":[{"given":"Tuhina","family":"Dey","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Leishmania Group, Indian Institute of Chemical Biology, Calcutta 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairul","family":"Anam","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Leishmania Group, Indian Institute of Chemical Biology, Calcutta 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhat","family":"Afrin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Leishmania Group, Indian Institute of Chemical Biology, Calcutta 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Ali","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Leishmania Group, Indian Institute of Chemical Biology, Calcutta 700032, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2371-2377.1997"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0163-7258(83)90010-4","article-title":"Delivery of liposome-encapsulated drugs to macrophages.","volume":"22","author":"Alving C. R.","year":"1983","unstructured":"Alving C. R. Delivery of liposome-encapsulated drugs to macrophages. Pharmacol. Ther. 22 1983 407 424","journal-title":"Pharmacol. Ther."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/24.4.684"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0035-9203(77)90155-9","article-title":"The use of Pentostam liposomes in the chemotherapy of experimental leishmaniasis.","volume":"71","author":"Black C. D. V.","year":"1977","unstructured":"Black C. D. V. Watson G. J. Ward R. J. The use of Pentostam liposomes in the chemotherapy of experimental leishmaniasis. Trans. R. Soc. Trop. Med. Hyg. 71 1977 550 552","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"e_1_3_2_6_2","unstructured":"Bryceson\n              A. D. M.\n          Therapy in man\n          Leishmaniasis in biology and medicine.\n              Killick\n              P. W.\n              Kendrick\n              R.\n          1987\n          848\n          907\n          Academic Press Ltd.\n          London England"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0140-6736(91)91708-3","article-title":"Liposomal amphotericin B in drug resistant visceral leishmaniasis.","volume":"337","author":"Davidson R. N.","year":"1991","unstructured":"Davidson R. N. Croft S. L. Scott A. Miani M. Moody A. H. Bryceson A. D. M. Liposomal amphotericin B in drug resistant visceral leishmaniasis. Lancet 337 1991 1061 1062","journal-title":"Lancet"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0014-4894(77)90107-2","article-title":"Leishmania donovani: surface membrane carbohydrates of promastigotes.","volume":"41","author":"Dwyer D. M.","year":"1977","unstructured":"Dwyer D. M. Leishmania donovani: surface membrane carbohydrates of promastigotes. Exp. 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