{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:07:41Z","timestamp":1787047661568,"version":"build-2736575974"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Emtricitabine [(\u2212)FTC] [(\u2212)-\u03b2-2\u2032,3\u2032-dideoxy-5-fluoro-3\u2032-thiacytidine] has been shown to be an effective inhibitor of hepatitis B virus (HBV) in cell culture, with a potency and selectivity that are essentially identical to those of lamivudine. The antiviral activity of oral administration of (\u2212)FTC against WHV replication in chronically infected woodchucks, an established and predictive model for antiviral therapy against HBV, was examined in a placebo-controlled study. (\u2212)FTC significantly reduced viremia and intrahepatic WHV replication in a dose-dependent manner that was comparable to the antiviral activity of lamivudine observed in previous studies conducted by our laboratories. No effect on the levels of hepatic WHV RNA or the levels of woodchuck hepatitis surface antigen or anti-woodchuck hepatitis surface and core antibodies in the serum of the treated animals was observed. No evidence of drug-related toxicity was observed in any of the animals treated.<\/jats:p>","DOI":"10.1128\/aac.44.6.1757-1760.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1757-1760","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks"],"prefix":"10.1128","volume":"44","author":[{"given":"Brent E.","family":"Korba","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"Schinazi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Veterans Administration Hospital, Emory University, Decatur, Georgia2; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cote","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland1;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bud C.","family":"Tennant","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->College of Veterinary Medicine, Cornell University, Ithaca, New York3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Gerin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland1;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/jps.2600830122","article-title":"Pharmacokinetics of 2\u2032,3\u2032-dideoxy-5-fluoro-3\u2032-thiacytidine in rats.","volume":"83","author":"Abobo C. V.","year":"1994","unstructured":"Abobo C. V. Ni L. Schinazi R. F. Liotta D. C. Boudinot F. D. Pharmacokinetics of 2\u2032,3\u2032-dideoxy-5-fluoro-3\u2032-thiacytidine in rats. J. Pharm. Sci. 83 1994 96 99","journal-title":"J. Pharm. Sci."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.1993.6.161"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2076"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.12.2921"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.12.2686"},{"key":"e_1_3_2_7_2","unstructured":"Ganem\n              D.\n          Hepadnaviridae: the viruses and their replication\n          Fields virology\n          3rd ed.\n              Fields\n              B. N.\n              Knipe\n              D. M.\n              Howley\n              P. M.\n          1996\n          2703\n          2737\n          Lippincott-Raven\n          Philadelphia Pa"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF02779926","article-title":"Experimental WHV infection of woodchucks: an animal model of hepadnavirus-induced liver cancer.","volume":"25","author":"Gerin J. L.","year":"1990","unstructured":"Gerin J. L. Experimental WHV infection of woodchucks: an animal model of hepadnavirus-induced liver cancer. Gastroenterol. Jpn. 25 (Suppl.) 1990 38 42","journal-title":"Gastroenterol. Jpn."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1292"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.11.2804"},{"key":"e_1_3_2_11_2","unstructured":"Korba B. B. Baldwin W. Hornbuckle P. Cote B. Tennant and J. Gerin. Treatment of chronic WHV infection in the Eastern woodchuck ( Marmota monax ) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in man. Hepatology in press."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.58.1.1-8.1986"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9150"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.12.9392-9399.1997"},{"key":"e_1_3_2_15_2","unstructured":"National Academy of Sciences\n          Guide for the care and use of laboratory animals.\n          1996\n          National Academy Press\n          Washington D.C."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.52.1.70-76.1984"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.3.642"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.11.2432"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.9.2172"},{"key":"e_1_3_2_20_2","unstructured":"Tennant\n              B.\n              Gerin\n              J.\n          The woodchuck model of hepatitis B infection\n          The liver: biology and pathobiology.\n              Arias\n              I.\n              Boyer\n              J.\n              Fausto\n              N.\n              Jacoby\n              W.\n              Schachter\n              D.\n              Shafritz\n              D.\n          1994\n          1455\n          1466\n          Raven Press\n          New York N.Y"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280124"},{"key":"e_1_3_2_22_2","unstructured":"Tennant\n              B. C.\n              Hornbuckle\n              W. E.\n              Baldwin\n              B. H.\n              King\n              J. M.\n              Cote\n              P.\n              Popper\n              H.\n              Purcell\n              R. H.\n              Gerin\n              J. L.\n          Influence of age on the response to experimental woodchuck hepatitis virus infection\n          Viral hepatitis liver disease.\n              Zuckerman\n              A. J.\n          1988\n          462\n          464\n          Alan R. Liss Inc.\n          New York N.Y"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.6.1757-1760.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.6.1757-1760.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:54:16Z","timestamp":1645462456000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.44.6.1757-1760.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["10.1128\/AAC.44.6.1757-1760.2000"],"URL":"https:\/\/doi.org\/10.1128\/aac.44.6.1757-1760.2000","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]},"assertion":[{"value":"1999-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}