{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:48:41Z","timestamp":1787921321504,"version":"build-2784847793"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Twenty clinical isolates of<jats:italic>Histoplasma capsulatum<\/jats:italic>were tested for their in vitro susceptibilities to caspofungin in comparison to those to amphotericin B by following National Committee for Clinical Laboratory Standards guidelines for yeasts. The mean MICs were 16.6 \u03bcg\/ml (range, 8 to 32 \u03bcg\/ml) for caspofungin and 0.56 \u03bcg\/ml (range, 0.5 to 1.0 \u03bcg\/ml) for amphotericin B. Survival experiments used a 10<jats:sup>5<\/jats:sup>dose in a pulmonary challenge model with B6C3F<jats:sub>1<\/jats:sub>mice. All mice that received amphotericin B at 2 mg\/kg of body weight every other day (q.o.d.), 30% of mice that received caspofungin at 8 mg\/kg\/day, and 20% of mice that received caspofungin at 4 mg\/kg\/day survived to day 15, while mice that received caspofungin at 2 mg\/kg\/day and all control mice that received the vehicle died by day 14. Amphotericin B at 2 mg\/kg q.o.d. markedly reduced the fungal burden in the lungs and spleens, as measured by<jats:italic>Histoplasma<\/jats:italic>antigen detection techniques and quantitative cultures, for each comparison. Caspofungin at 10 mg\/kg twice a day (b.i.d.) did not reduce the fungal burden, as measured by antigen detection techniques, but slightly reduced the levels of fungi in both the lungs and spleens, as determined by quantitative cultures. Caspofungin at 5 mg\/kg b.i.d. did not affect fungal burden. Overall, caspofungin had only a slight effect on survival or fungal burden.<\/jats:p>","DOI":"10.1128\/aac.44.7.1850-1854.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1850-1854","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["Comparison of the Echinocandin Caspofungin with Amphotericin B for Treatment of Histoplasmosis following Pulmonary Challenge in a Murine Model"],"prefix":"10.1128","volume":"44","author":[{"given":"Steve","family":"Kohler","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Veterans' Affairs Hospital,1"},{"name":"<!--label omitted: 2-->Indiana University School of Medicine, and Histoplasmosis Reference Laboratory,2 Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Joseph","family":"Wheat","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Veterans' Affairs Hospital,1"},{"name":"<!--label omitted: 3-->Departments of Medicine,3 and"},{"name":"<!--label omitted: 4-->Pathology,4"},{"name":"<!--label omitted: 2-->Indiana University School of Medicine, and Histoplasmosis Reference Laboratory,2 Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Connolly","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departments of Medicine,3 and"},{"name":"<!--label omitted: 2-->Indiana University School of Medicine, and Histoplasmosis Reference Laboratory,2 Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Schnizlein-Bick","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departments of Medicine,3 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Durkin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departments of Medicine,3 and"},{"name":"<!--label omitted: 2-->Indiana University School of Medicine, and Histoplasmosis Reference Laboratory,2 Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Smedema","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departments of Medicine,3 and"},{"name":"<!--label omitted: 2-->Indiana University School of Medicine, and Histoplasmosis Reference Laboratory,2 Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Goldberg","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departments of Medicine,3 and"},{"name":"<!--label omitted: 2-->Indiana University School of Medicine, and Histoplasmosis Reference Laboratory,2 Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Brizendine","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Departments of Medicine,3 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1077"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2326"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1070"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00028a003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.2.322"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/00031305.1981.10479327","article-title":"Rank transformations as a bridge between parametric and nonparametric statistics.","volume":"35","author":"Conover W. 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Bartlett M. S. Ghannoum M. A. Espinel-Ingroff A. Lancaster M. V. Odds F. C. Pfaller M. A. Rex J. H. Rinaldi M. G. Walsh T. J. Galgiani J. N. Reference method of broth dilution antifungal susceptibility testing of yeasts 1997 1 29 Approved standard M27-A. 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