{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:44:28Z","timestamp":1793018668260,"version":"4.5.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To examine the efficacy and safety of short courses of azithromycin and ofloxacin for treating multidrug-resistant (MDR, i.e., resistant to chloramphenicol, ampicillin, and cotrimoxazole) and nalidixic acid-resistant enteric fever, azithromycin (1 g once daily for 5 days at 20 mg\/kg\/day) and ofloxacin (200 mg orally twice a day for 5 days at 8 mg\/kg\/day) were compared in an open randomized study in adults admitted to a hospital with uncomplicated enteric fever. A total of 88 blood culture-confirmed patients were enrolled in the study (86 with\n            <jats:italic>Salmonella enterica<\/jats:italic>\n            serovar Typhi and 2 with\n            <jats:italic>S. enterica<\/jats:italic>\n            serovar Paratyphi A). Of these, 44 received azithromycin and 44 ofloxacin. A total of 68 of 87 (78%) isolates were MDR serovar Typhi, and 46 of 87 (53%) were nalidixic acid resistant. The MIC\n            <jats:sub>90<\/jats:sub>\n            (range) of azithromycin was 8 (4 to 16) \u03bcg\/ml for the isolates. The MIC\n            <jats:sub>90<\/jats:sub>\n            (range) of ofloxacin for the nalidixic acid-sensitive isolates was 0.03 (0.015 to 0.06) \u03bcg\/ml and for the nalidixic acid-resistant isolates it was 0.5 (0.25 to 1.0) \u03bcg\/ml. There was no significant difference in the overall clinical cure rate with ofloxacin and azithromycin (38 of 44 [86.4%] versus 42 of 44 [95.5%];\n            <jats:italic>P<\/jats:italic>\n            = 0.27) or in the patients infected with nalidixic acid-resistant typhoid (17 of 21 [81.0%] versus 24 of 25 [96.0%];\n            <jats:italic>P<\/jats:italic>\n            = 0.16). However, patients with nalidixic acid-resistant typhoid treated with ofloxacin had a longer fever clearance time compared with those treated with azithromycin (174 [60 to 264] versus 135 [72 to 186] h;\n            <jats:italic>P<\/jats:italic>\n            = 0.004) and had positive fecal cultures after the end of treatment (7 of 17 [41%] versus 0 of 19 [0%];\n            <jats:italic>P<\/jats:italic>\n            = 0.002). Both antibiotics were well tolerated. A 5-day course of azithromycin was effective for the treatment of enteric fever due to MDR and nalidixic-acid-resistant serovar Typhi, whereas the ofloxacin regimen chosen was less satisfactory for these strains.\n          <\/jats:p>","DOI":"10.1128\/aac.44.7.1855-1859.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"1855-1859","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":102,"title":["A Randomized Controlled Comparison of Azithromycin and Ofloxacin for Treatment of Multidrug-Resistant or Nalidixic Acid-Resistant Enteric Fever"],"prefix":"10.1128","volume":"44","author":[{"given":"Nguyen Tran","family":"Chinh","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases, Faculty of Medicine, University of Medicine and Pharmacy,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Parry","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Wellcome Trust Clinical Research Unit,2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Ly","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Infectious Diseases, Faculty of Medicine, University of Medicine and Pharmacy,1and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh Duy","family":"Ha","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Centre for Tropical Diseases,3 Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Xuan","family":"Thong","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Centre for Tropical Diseases,3 Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"To Song","family":"Diep","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Centre for Tropical Diseases,3 Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wain","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Wellcome Trust Clinical Research Unit,2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Wellcome Trust Clinical Research Unit,2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Farrar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Wellcome Trust Clinical Research Unit,2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/jac\/33.6.1258","article-title":"Ciprofloxacin resistance in Salmonella paratyphi A.","volume":"33","author":"Brown N. 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