{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:37:35Z","timestamp":1773221855719,"version":"3.50.1"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            MICs, time-kills, and postantibiotic effects (PAEs) of ABT-773 (a new ketolide) and 10 other agents were determined against 226 pneumococci. Against 78\n            <jats:italic>ermB<\/jats:italic>\n            - and 44\n            <jats:italic>mefE<\/jats:italic>\n            -containing strains, ABT-773 MICs at which 50% of the isolates tested were inhibited (MIC\n            <jats:sub>50<\/jats:sub>\n            s) and MIC\n            <jats:sub>90<\/jats:sub>\n            s were 0.016 to 0.03 and 0.125 \u03bcg\/ml, respectively. Clindamycin was active only against macrolide-resistant strains containing\n            <jats:italic>mefE<\/jats:italic>\n            (MIC\n            <jats:sub>50<\/jats:sub>\n            , 0.06 \u03bcg\/ml; MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.125 \u03bcg\/ml). Activities of pristinamycin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.5 \u03bcg\/ml) and vancomycin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.25 \u03bcg\/ml) were unaffected by macrolide or penicillin resistance, while \u03b2-lactam MICs rose with those of penicillin G. Against 19 strains with L4 ribosomal protein mutations and two strains with mutations in domain V of 23S rRNA, ABT-773 MICs were 0.03 to 0.25 \u03bcg\/ml, while macrolide and azalide MICs were all \u226516.0 \u03bcg\/ml. ABT-773 was bactericidal at twice the MIC after 24 h for 8 of 12 strains (including three strains with erythromycin MICs greater than or equal to 64.0 \u03bcg\/ml). Kill kinetics of erythromycin, azithromycin, clarithromycin, and roxithromycin against macrolide-susceptible strains were slower than those of ABT-773. ABT-773 had longer PAEs than macrolides, azithromycin, clindamycin, or \u03b2-lactams, including against\n            <jats:italic>ermB<\/jats:italic>\n            -containing strains. ABT-773, therefore, shows promising in vitro activity against macrolide-susceptible as well as -resistant pneumococci.\n          <\/jats:p>","DOI":"10.1128\/aac.44.7.1894-1899.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"1894-1899","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Antipneumococcal Activity of ABT-773 Compared to Those of 10 Other Agents"],"prefix":"10.1128","volume":"44","author":[{"given":"Todd A.","family":"Davies","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois M.","family":"Ednie","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne M.","family":"Hoellman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn A.","family":"Pankuch","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Pathology, Case Western Reserve University, Cleveland, Ohio 441062"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/clinids\/15.1.77","article-title":"Antimicrobial resistance in Streptococcus pneumoniae\u2014an overview.","volume":"15","author":"Appelbaum P. 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