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The SCH 56592 MICs for\n            <jats:italic>Aspergillus<\/jats:italic>\n            ranged from \u22640.002 to 0.5 \u03bcg\/ml, and those of itraconazole ranged from \u22640.008 to 1 \u03bcg\/ml. The SCH 56592 MICs for\n            <jats:italic>Candida<\/jats:italic>\n            and\n            <jats:italic>Cryptococcus<\/jats:italic>\n            strains ranged from \u22640.004 to 16 \u03bcg\/ml, and those of fluconazole ranged from \u22640.062 to &gt;64 \u03bcg\/ml. SCH 56592 showed excellent activity against\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            and\n            <jats:italic>Aspergillus flavus<\/jats:italic>\n            in a pulmonary mouse infection model. When administered therapeutically, the 50% protective doses (PD\n            <jats:sub>50<\/jats:sub>\n            s) of SCH 56592 ranged from 3.6 to 29.9 mg\/kg of body weight, while the PD\n            <jats:sub>50<\/jats:sub>\n            s of SCH 56592 administered prophylactically ranged from 0.9 to 9.0 mg\/kg; itraconazole administered prophylactically was ineffective (PD\n            <jats:sub>50<\/jats:sub>\n            s, &gt;75 mg\/kg). SCH 56592 was also very efficacious against fluconazole-susceptible, -susceptible dose-dependent, or -resistant\n            <jats:italic>Candida albicans<\/jats:italic>\n            strains in immunocompetent or immunocompromised mouse models of systemic infection. The PD\n            <jats:sub>50<\/jats:sub>\n            s of SCH 56592 administered therapeutically ranged from 0.04 to 15.6 mg\/kg, while the PD\n            <jats:sub>50<\/jats:sub>\n            s of SCH 56592 administered prophylactically ranged from 1.5 to 19.4 mg\/kg. SCH 56592 has excellent potential for therapy against serious\n            <jats:italic>Aspergillus<\/jats:italic>\n            or\n            <jats:italic>Candida<\/jats:italic>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/aac.44.8.2017-2022.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:06:42Z","timestamp":1027764402000},"page":"2017-2022","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":78,"title":["In Vitro and In Vivo Activities of SCH 56592 (Posaconazole), a New Triazole Antifungal Agent, against\n            <i>Aspergillus<\/i>\n            and\n            <i>Candida<\/i>"],"prefix":"10.1128","volume":"44","author":[{"given":"Anthony","family":"Cacciapuoti","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Loebenberg","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Corcoran","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Fred","family":"Menzel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Eugene L.","family":"Moss","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Norris","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Michalski","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Raynor","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Halpern","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara","family":"Mendrick","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Arnold","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Antonacci","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raulo","family":"Parmegiani","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisa","family":"Yarosh-Tomaine","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George H.","family":"Miller","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta S.","family":"Hare","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2116"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"S1591","DOI":"10.1093\/clinids\/11.Supplement_7.S1591","article-title":"Problems in management of opportunistic fungal diseases.","volume":"11","author":"Armstrong D.","year":"1989","unstructured":"Armstrong D. 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