{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:13:11Z","timestamp":1776705191075,"version":"3.51.2"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro activities of GAR-936, the 9-\n            <jats:italic>t<\/jats:italic>\n            -butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of \u22642 \u03bcg\/ml, except two strains of JK diphtheroids for which the MIC was 4 \u03bcg\/ml.\n          <\/jats:p>","DOI":"10.1128\/aac.44.8.2225-2229.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"2225-2229","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":81,"title":["In Vitro Activities of the Glycylcycline GAR-936 against Gram-Positive Bacteria"],"prefix":"10.1128","volume":"44","author":[{"given":"Helen W.","family":"Boucher","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215,1and"},{"name":"<!--label omitted: 2-->Harvard Medical School, Boston, Massachusetts 021152"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine B.","family":"Wennersten","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215,1and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Eliopoulos","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215,1and"},{"name":"<!--label omitted: 2-->Harvard Medical School, Boston, Massachusetts 021152"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"597","article-title":"Nosocomial enterococci resistant to vancomycin\u2014United States, 1989\u20131993.","volume":"42","author":"Centers for Disease Control and Prevention","year":"1993","unstructured":"Centers for Disease Control and Prevention Nosocomial enterococci resistant to vancomycin\u2014United States, 1989\u20131993. Morb. Mortal. Wkly. Rep. 42 1993 597 599","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.3.598"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.6.1234"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/jac\/9.suppl_C.143","article-title":"In vitro activity of Sch 29482 in comparison with other oral antibiotics.","volume":"9","author":"Eliopoulos G. M.","year":"1982","unstructured":"Eliopoulos G. M. Gardella A. Moellering R. C. Jr. In vitro activity of Sch 29482 in comparison with other oral antibiotics. J. Antimicrob. Chemother. 9 (Suppl. C) 1982 143 152","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.3.534"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70393-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1086\/514752","article-title":"Determinants of vancomycin use in adult intensive care units in 41 United States hospitals.","volume":"28","author":"Fridkin S. K.","year":"1999","unstructured":"Fridkin S. K. Edwards J. R. Pichette S. C. Pryor E. R. McGowan J. E. Jr. Tenover F. C. Culver D. H. Gaynes R. P. Determinants of vancomycin use in adult intensive care units in 41 United States hospitals. Clin. Infect. Dis. 28 1999 1119 1125","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199611073351907"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1001\/archinte.159.13.1437","article-title":"Risk factors for hospital-acquired Staphylococcus aureus bacteremia.","volume":"159","author":"Jensen A. G.","year":"1999","unstructured":"Jensen A. G. Wachmann C. H. Poulsen K. B. Espersen F. Scheibel J. Pkinhoj P. Frimodt-Moeller N. Risk factors for hospital-acquired Staphylococcus aureus bacteremia. Arch. Intern. Med. 159 1999 1437 1444","journal-title":"Arch. Intern. Med."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/514743"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1086\/520288","article-title":"Problems with antimicrobial resistance in gram-positive cocci.","volume":"26","author":"Moellering R. C.","year":"1998","unstructured":"Moellering R. C. Jr. Problems with antimicrobial resistance in gram-positive cocci. Clin. Infect. Dis. 26 1998 1177 1178","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_13_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically\n          4th ed.\n          1997 Approved standard M7-A4. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1001\/archinte.159.13.1467","article-title":"Vancomycin-resistant enterococci in intensive care units.","volume":"159","author":"Ostrowsky B. E.","year":"1999","unstructured":"Ostrowsky B. E. Venkataraman L. D'Agata E. M. C. Gold H. S. DeGirolami P. C. Samore M. H. Vancomycin-resistant enterococci in intensive care units. Arch. Intern. Med. 159 1999 1467 1472","journal-title":"Arch. Intern. Med."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.738"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.7.1658"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJM199012273232606","article-title":"Rapid dissemination of \u03b2-lactamase-producing aminoglycoside-resistant Enterococcus faecalis among patients and staff on an infant-toddler surgical ward.","volume":"323","author":"Rhinehart E.","year":"1990","unstructured":"Rhinehart E. Smith N. E. Wennersten C. Gorss E. Freeman J. Eliopoulos G. M. Moellering R. C. Jr. Goldmann D. A. Rapid dissemination of \u03b2-lactamase-producing aminoglycoside-resistant Enterococcus faecalis among patients and staff on an infant-toddler surgical ward. N. Engl. J. Med. 323 1990 1814 1818","journal-title":"N. Engl. J. Med."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.8.2225-2229.2000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.44.8.2225-2229.2000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:48:58Z","timestamp":1645462138000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.44.8.2225-2229.2000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1128\/AAC.44.8.2225-2229.2000"],"URL":"https:\/\/doi.org\/10.1128\/aac.44.8.2225-2229.2000","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]},"assertion":[{"value":"2000-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}